20 documents found, page 1 of 2
Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmentin...
Mota, Sandra; Rosa, Gonçalo P.; Barreto, Maria Carmo; Garrido, Jorge; Sousa, Emília; Cruz, Maria T.; Almeida, Isabel F.; Quintas, Clara; Garrido, JorgeDepigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid—for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase ...
Unraveling fiscalin derivatives' interactions with P-glycoprotein: a computatio...
Veiga-Matos, Jéssica; dos Santos, Daniel J. V. A.; Sousa, Emília; Morales, Ana; Prieto, Marta; Remião, Fernando; Silva, RenataBackground: P-glycoprotein (P-gp), a crucial efflux transporter located on the apical membrane of vital barrier tissues, plays a critical role in the detoxification of several endobiotics and xenobiotics [1,2]. Notably, fiscalin derivatives exhibit diverse interactions with P-gp, demonstrating inhibitory or activating effects. This interaction leads to a reduction or increase in the transported substrate levels...
A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitiz...
Jesus, Ana; Sebastião, Ana I.; Brites, Gonçalo; Correia-da-Silva, Marta; Cidade, Honorina; Cruz, Maria T.; Sousa, Emília; Almeida, Isabel F.Resveratrol (RSV), a naturally occurring metabolite, is widely used in skincare products, but its hydrophobicity impairs its own incorporation into cosmetic formulations. RSV-GS is a synthetic hydrophilic sulfated glycosylated derivative inspired by marine natural products that present a lower cytotoxicity than RSV while exhibiting similar levels of bioactivity. Herein, we predict the skin sensitization potenti...
How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strate...
Torres, Ana; Rego, Liliana; Martins, Márcia S.; Ferreira, Marta S.; Cruz, Maria T.; Sousa, Emília; Almeida, Isabel F.Skin repair encompasses epidermal barrier repair and wound healing which involves multiple cellular and molecular stages. Therefore, many skin repair strategies have been proposed. In order to characterize the usage frequency of skin repair ingredients in cosmetics, medicines, and medical devices, commercialized in Portuguese pharmacies and parapharmacies, a comprehensive analysis of the products' composition w...
Antioxidants in Sunscreens: Which and What For?
Jesus, Ana; Mota, Sandra; Torres, Ana; Cruz, Maria T.; Sousa, Emília; Almeida, Isabel F.; Cidade, HonorinaUltraviolet (UV) radiation promotes the generation of reactive oxygen species (ROS) and nitrogen species (RNS), resulting in skin damage. Cosmetic industries have adopted a strategy to incorporate antioxidants in sunscreen formulations to prevent or minimize UV-induced oxidative damage, boost photoprotection effectiveness, and mitigate skin photoaging. Many antioxidants are naturally derived, mainly from terres...
Comparative studies on the photoreactivity, efficacy, and safety of depigmentin...
Mota, Sandra; Rosa, Gonçalo P.; Barreto, Maria Carmo; Garrido, Jorge; Sousa, Emília; Cruz, Maria T.; Almeida, Isabel F.; Quintas, ClaraDepigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid—for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase ...
Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmentin...
Mota, Sandra; Rosa, Gonçalo P.; Barreto, Maria Carmo; Garrido, Jorge; Sousa, Emília; Cruz, Maria Teresa; Almeida, Isabel F.; Quintas, ClaraDepigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid—for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase ...
UV Filters: Challenges and Prospects
Jesus, Ana; Sousa, Emília; Cruz, Maria T.; Cidade, Honorina; Lobo, José M. Sousa; Almeida, Isabel F.The use of sunscreens is an established and recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union, which ought to follow the requirements of the regulation 1223/2009 to ensure their efficacy and safety for humans. Nevertheless, low photostability and putative toxicity for humans and environment have been reported for some UV ...
Up-to-Date Overview of the Use of Natural Ingredients in Sunscreens
Resende, Diana I. S. P.; Jesus, Ana; Lobo, José M. Sousa; Sousa, Emília; Cruz, Maria T.; Cidade, Honorina; Almeida, Isabel F.The photoprotective skincare segment is in high demand to meet consumer concerns on UV-induced skin damage, with a recent trend towards sunscreen alternatives with a natural origin. In this study, the use of natural ingredients, either from terrestrial or marine origin, in a panel of 444 sunscreen commercial formulations (2021) was analyzed. Ingredients from terrestrial organisms represent the large majority fo...
Effect of 1-carbaldehyde-3,4-dimethoxyxanthone on prostate and HPV-18 positive ...
Medeiros, R.; Horta, Bruno; Freitas-Silva, Joana; Silva, Jani; Dias, Francisca; Sousa, Emília; Pinto, Madalena; Cerqueira, FátimaXanthone derivatives have shown promising antitumor properties, and 1-carbaldehyde-3,4- dimethoxyxanthone (1) has recently emerged as a potent tumor cell growth inhibitor. In this study, its effect was evaluated (MTT viability assay) against a new panel of cancer cells, namely cervical cancer (HeLa), androgen-sensitive (LNCaP) and androgen-independent (PC-3) prostate cancer, and nonsolid tumor derived cancer (J...