30 documents found, page 1 of 3
Efficient solid-phase RNA extraction using carbon nanomaterials
Videira, AM; Ferreira, PL; Sampaio, M.J.; Serp, P; Faria, JL; Silva, CG; Sousa, FRecent research highlights RNA's ' s therapeutic potential in nucleic acid-based therapies. However, effective RNA recovery and purification remain challenging due to similar impurities affecting therapeutic outcomes. Traditional RNA isolation methods are often slow, inefficient, and involve toxic reagents. Carbon-based materials offer a promising alternative as adsorbents for nucleic acids due to their excelle...
A Genotyping-by-Sequencing approach brings new insights into the population str...
Galhofa, D; Viegas, M; Sousa, F; Henriques, A; Sousa, P; Pina-Martins, F; Vanhove, M; Silva, A; Batista, D; Goulier-Lagadec, J; Galinat, F; Rzigui, T
Late Onset Neuromyelitis Optica Spectrum Disorders (LONMOSD) from a Nationwide ...
Santos, E; Moura, J; Samões, R; Sousa, AP; Mendonça, T; Abreu, P; Guimarães, J; Correia, I; Durães, J; Sousa, L; Ferreira, J; de Sá, J; Sousa, FIntroduction: Several neuroimmunological disorders have distinct phenotypes according to the age of onset, as in multiple sclerosis or myasthenia gravis. It is also described that late onset NMOSD (LONMOSD) has a different phenotype. Objective: To describe the clinical/demographic characteristics of the LONMOSD and distinguish them from those with early onset (EONMOSD). Methods: From a nationwide Portuguese NMO...
Neuromyelitis optica spectrum disorders: A nationwide Portuguese clinical epide...
Santos, E; Rocha, AL; Oliveira, V; Ferro, D; Samões, R; Sousa, P; Figueiroa, S; Mendonça, T; Abreu, P; Guimarães, J; Sousa, R; Melo, C; Correia, IIntroduction: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disorder in which astrocyte damage and/or demyelination often cause severe neurological deficits. Objective: To identify Portuguese patients with NMOSD and assess their epidemiological/clinical characteristics. Methods: This was a nationwide multicenter study. Twenty-four Portuguese adult and 3 neuropediatric centers following NMOSD patients...
Neuromyelitis optica spectrum disorders: A nationwide Portuguese clinical epide...
Santos, E; Rocha, AL; Oliveira, V; Ferro, D; Samões, R; Sousa, AP; Figueiroa, S; Mendonça, T; Abreu, P; Guimarães, J; Sousa, R; Melo, C; Correia, IIntroduction: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disorder in which astrocyte damage and/or demyelination often cause severe neurological deficits. Objective: To identify Portuguese patients with NMOSD and assess their epidemiological/clinical characteristics. Methods: This was a nationwide multicenter study. Twenty-four Portuguese adult and 3 neuropediatric centers following NMOSD patients...
The adaptive immune landscape of the colorectal adenoma–carcinoma sequence
Freitas, JA; Gullo, I; Garcia, D; Miranda, S; Spaans, L; Pinho, L; Reis, J; Sousa, F; Baptista, M; Resende, C; Leitão, D; Durães, C; Costa, JLBackground. The tumor immune microenvironment exerts a pivotal influence in tumor initiation and progression. The aim of this study was to analyze the immune context of sporadic and familial adenomatous polyposis (FAP) lesions along the colorectal adenoma–carcinoma sequence (ACS). Methods. We analyzed immune cell counts (CD3+, CD4+, CD8+, Foxp3+, and CD57+), tumor mutation burden (TMB), MHC-I expression and PD-...
An anaphase surveillance mechanism prevents micronuclei formation from frequent...
Orr, B; Sousa, F; Gomes, AM; Afonso, O; Ferreira, LT; Figueiredo, AC; Maiato, HMicronuclei are a hallmark of cancer and several other human disorders. Recently, micronuclei were implicated in chromothripsis, a series of massive genomic rearrangements that may drive tumor evolution and progression. Here, we show that Aurora B kinase mediates a surveillance mechanism that integrates error correction during anaphase with spatial control of nuclear envelope reassembly to prevent micronuclei f...
Portuguese Football Federation consensus statement 2020: nutrition and performa...
Abreu, R; Figueiredo, P; Beckert, P; Marques, JP; Amorim, S; Caetano, C; Carvalho, P; Sa, C; Cotovio, R; Cruz, J; Dias, T; Fernandes, G; Goncalves, ENutrition is an undeniable part of promoting health and performance among football (soccer) players. Nevertheless, nutritional strategies adopted in elite football can vary significantly depending on culture, habit and practical constraints and might not always be supported by scientific evidence. Therefore, a group of 28 Portuguese experts on sports nutrition, sports science and sports medicine sought to discu...
Neuromyelitis Optica Spectrum Disorders: a Nationwide Portuguese Clinical Epide...
Santos, E; Rocha, AL; Oliveira, V; Ferro, D; Samões, R; Sousa, AP; Figueiroa, S; Mendonça, T; Abreu, P; Guimarães, J; Sousa, R; Melo, C; Correia, IIntroduction: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disorder in which astrocyte damage and/or demyelination often cause severe neurological deficits. Objective: To identify Portuguese patients with NMOSD and assess their epidemiological/clinical characteristics. Methods: This was a nationwide multicenter study. Twenty-four Portuguese adult and 3 neuropediatric centers following NMOSD patients...
Trauma
Castro, J; Blamey, C; Vicente, M; Sousa, F; Gamelas, P; Pereira, C; Mesquita, C