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Effects of dexamethasone and nimesulide on bisphosphonate-related osteonecrosis...
Oliveira, Camila Carvalho de; Silva, Paulo Goberlânio de Barros; Ferreira Jr., Antonio Ernando Carlos; Gonçalves, Romélia PinheiroObjective: To evaluate the e ff ects of dexamethasone (DEX) and nimesulide (NIM) on Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) in rats. Design: BRONJ was induced by zoledronic acid (ZA) infusion (0.2 mg/kg) in Wistar rats (n = 8), followed by extraction of the left lower fi rst molar (BRONJ groups). Control groups (n = 40) received saline (IV). For eight weeks, DEX (0.04, 0.4, 4 mg/kg) or saline (S...
Date: 2018
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Origin: Oasisbr