7 documents found, page 1 of 1
Glutaminemia prognostic significance in critical surgical patients - An analysi...
Costa, Beatriz Pinto; Martins, Paulo; Veríssimo, Carla; Simões, Marta; Tomé, Marisa; Grazina, Manuela; Pimentel, Jorge; Sousa, Francisco CastroBackground: Glutamine depletion is common in the critically-ill patients. Glutaminemia lower than 420 μmol/l has been considered as an independent predictive factor of mortality, but the indications for exogenous glutamine supplementation remain controversial. This study intends to determine the glutaminemia profi le in critical surgical patients and to investigate its correlation with the severity indexes and ...
Intestinal dysfunction in the critical trauma patients - An early and frequent ...
Costa, Beatriz Pinto; Martins, Paulo; Veríssimo, Carla; Simões, Marta; Tomé, Marisa; Grazina, Manuela; Pimentel, Jorge; Sousa, Francisco CastroBackground: Small-bowel dysfunction exerts a relevant prognostic impact in the critically ill patients. Citrullinemia has been used in the evaluation of the intestinal function and it is considered an objective parameter of the functional enterocyte mass. Present study proposes to determine the intestinal dysfunction prevalence and the citrullinemia kinetic profi le in severe trauma patients and to investigate ...
Argininemia and plasma arginine bioavailability - predictive factors of mortali...
Costa, Beatriz P.; Martins, Paulo; Veríssimo, Carla; Simões, Marta; Tomé, Marisa; Grazina, Manuela; Pimentel, Jorge; Sousa, Francisco CastroBackground: Arginine is an amino acid determinant in the metabolic, immune and reparative responses to severe trauma. The present study aims to determine argininemia and plasma arginine bioavailability (PAB) in critical trauma patients and to analyze its correlation with prognosis. Methods: A prospective study of 23 critical trauma patients was undertaken. Aminoacidemias were determined, by ion exchange chromat...
Oxaliplatin toxicity presenting as a liver nodule - case report
Alexandrino, Henrique; Oliveira, Domingos; Cipriano, Maria Augusta; Ferreira, Luís; Tralhão, J. Guilherme; Sousa, Francisco CastroBackground: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Her...
Study of hepatocellular function in the murine model following hepatic artery s...
Tralhão, José Guilherme; Abrantes, Ana M.; Gonçalves, Ana Cristina; Hoti, Emir; Laranjo, Mafalda; Martins, Ricardo Jorge Teixeira; Oliveiros, BárbaraPURPOSE: To investigate the impact of selective hepatic artery clamping (SHAC) in hepatocellular function. METHODS: Three groups of Wistar male rats were subjected to SHAC ischemia period of 60min: Group A continuous SHAC were subjected to SHAC ischemia period of 60min, Group B intermittent SHAC of 30min with 5min of reperfusion and Group C intermittent SHAC of 15min with 5min of reperfusion. Animals without SH...
Intrahepatic Colangiocarcinoma
Sousa, Francisco Castro; da Silva, Edgar Tavares; Tralhão, José Guilherme; Costa, Beatriz; Martins, Mónica; Serôdio, Marco; Martins, RicardoIntroduction: intrahepatic cholangiocarcinoma (CCIhp) is a rare malignant tumor usually diagnosed at an advanced stage. This study intends to assess the treatment results of CCIhp and to define the prognostic factors of survival in treated at our department. Material and methods: Twenty-one patients undergoing treatment for CCIhp in recent years, of which eleven were operated with curative intent: four left hep...
M.E.L.D. in surgical risk evaluation of cirrhotic patients - Preliminary analys...
Costa, Beatriz Pinto da; Sousa, Francisco Castro; Carvalho, César; Serôdio, Marco; Moeria, JoanaIntroduction: Hepatic cirrhosis is a recognized surgical risk factor. Recent studies suggested that M.E.L.D. (Model for End-Stage Liver Disease) may represent a promising alternative to Child-Turcotte-Pugh classification as a predictive factor of operative mortality and morbidity; incorporation of serum sodium and age (iM.E.L.D.) seems to improve its prognostic potential. Objectives: To evaluate the utility of ...