38 documents found, page 1 of 4
TASTY trial: protocol for a study on the triad of nutrition, intestinal microbi...
Charneca, S; Hernando, A; Almada-Correia, I; Polido-Pereira, J; Vieira, A; Sousa, J; Almeida, AS; Motta, C; Barreto, G; Eklund, KK; Alonso-Pérez, ABackground The gut microbiota has been implicated in the onset and progression of Rheumatoid Arthritis (RA). It has been proposed that gut dysbiosis impairs gut barrier function, leading to alterations in mucosal integrity and immunity. This disruption allows bacterial translocation, contributing to the perpetuation of the inflammatory process. Since diet is recognised as a key environmental factor influencing ...
Necrotizing mesenteric vasculitis in systemic lupus erythematosus
Lourenço, MH; Bento Silva, A; Sousa, J; Oliveira, H; Silva, I; Costa, M; Branco, JC; Gonçalves, MJSystemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder which may affect the gastrointestinal system. Half of the patients with SLE experience gastrointestinal symptoms, with the most common being nausea, vomiting, anorexia, and abdominal pain. Mesenteric vasculitis is a severe and rare complication of SLE and one of the most frequent causes of severe acute abdominal pain. The authors present ...
Trauma Associado às Touradas à Corda nos Açores: Um Estudo Transversal
Vieira, B; Taranu, V; Vieira, A; Soares, D; Soares, A; Silva, A; Galvão, D; Bagnari, I; Melo, D; Pimentel, F; Sousa, J; Martins, L; Pinheiro, LIntroduction: The aim of the study was to describe trauma injuries associated with rope bullfights in the Azores, Portugal, regarding the cause of the incident, trauma mechanism, most affected anatomical areas, and injury severity. Methods: Two-year cross-sectional study in the local hospital with prospective data collection. Patients who were consecutively admitted to the local hospital’s emergency department ...
Kinetic Characterization of Pt/Al2O3 Catalyst for Hydrogen Production via Metha...
Sousa, J; Lakhtaria, P; Ribeirinha, P; Huhtinen, W; Tallgren, J; Adélio MendesCompared to steam reforming, methanol aqueous-phase reforming (APR) converts methanol to hydrogen and carbon dioxide at lower temperatures, but also displays lower conversion rates. Herein, methanol APR is studied over the active Pt/Al2O3 catalyst under different operating conditions. Studies were conducted at different temperatures, pressures, methanol mass fractions, and residence times. APR performance was e...
Blunt Trauma and Right Diaphragmatic Rupture: Unveiling the Impact
Alves, D; Sousa, J; Eurico Reis, J; Ribeiro, R; Calvinho, PTraumatic diaphragmatic ruptures are rare, yet blunt injuries tend to be more easily overlooked compared to penetrating trauma. The minimal evidence of external injuries makes a high index of suspicion key for diagnosis. We report the case of a right-sided thoracoabdominal blunt trauma that resulted in a diaphragmatic rupture and fractured rib. Although often approached through a midline laparotomy, a definitiv...
Antifouling Marine Coatings with a Potentially Safer and Sustainable Synthetic ...
Neves, AR; Luciana Gomes; Faria, SI; Sousa, J; Ruivo, R; Pascoa, I; Pinto, M; Emilia Sousa; Santos, MM; Silva, ER; Marta Correia da SilvaThe development of harmless substances to replace biocide-based coatings used to prevent or manage marine biofouling and its unwanted consequences is urgent. The formation of biofilms on submerged marine surfaces is one of the first steps in the marine biofouling process, which facilitates the further settlement of macrofoulers. Anti-biofilm properties of a synthetic polyphenolic compound, with previously descr...
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Sever...
Moreira-Rosário, A; Marques, C; Pinheiro, H; Araújo, JR; Ribeiro, P; Rocha, R; Mota, I; Pestana, D; Ribeiro, R; Pereira, A; Sousa, MJ; Pereira-Leal, JThe risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categoriz...
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic...
Sousa, J; Cá, B; Maceiras, AR; Simões-Costa, L; Fonseca, KL; Fernandes, AI; Ramos, A; Carvalho, T; Barros, L; Magalhães, C; Chiner-Oms, Á; Machado, HGenetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic...
Sousa, J; Cá, B; Maceiras, AR; Simões-Costa, L; Fonseca, KL; Fernandes, AI; Ramos, A; Carvalho, T; Barros, L; Magalhães, C; Chiner-Oms, Á; Machado, HGenetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neu...
Moreira-Teixeira, L; Stimpson, PJ; Stavropoulos, E; Hadebe, S; Chakravarty, P; Ioannou, M; Aramburu, IV; Herbert, E; Priestnall, SL; Suarez-Bonnet, ATuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were shown to correlate with disease severity in mouse models of TB. Here we show that similar transcriptional signatures correlate with increased bacterial loads and exacerbate pat...