6 documents found, page 1 of 1
Perfurações da membrana timpânica
Sousa, Jéssica; Queirós, Orlando; Tomé, DavidA perfuração da membrana timpânica (MT) é um problema otológico relativamente frequente nos dias atuais, causada, na maioria das vezes, por traumatismos. Esta patologia provoca comprometimento da impermeabilidade da membrana que separa o ouvido externo do médio, sendo que a colocação de um fragmento de celulose bacteriana tornou-se um método eficaz para a recuperação anatómica e fisiológica.
Anti-Forssman prevalence in a sample of the portuguese population and its chara...
Mourato, Cristiana; Sousa, Jéssica; Martins, Diana; Teixeira, Paulo; Rocha, Clara; Pereira, Cristina; Barreira, Rogério; Mendes, FernandoIntrodução Descoberto em 1911 por Frederick Forssman, a expressão do antigénio (Ag) Forssman (Fs) varia entre espécies, estando raramente presente nos eritrócitos humanos. Em 1987, três famílias inglesas sem qualquer relação entre si, foram identificadas com um fenótipo designado Apae que, mais tarde, foi classificado como o 31º grupo sanguíneo: FORS. Os anticorpos (Ac) anti-Fs têm ocorrência natural em humanos...
Widespread protein aggregation across the mouse lifespan
Martins, Filipa; Francisco, Stephany; Sousa, Jéssica; Pereira, Cátia D.; Correia, Liliana; Camões, Fátima; Helguero, Luísa; Soares, Ana RaquelAging is characterized by a gradual decline in overall organismal fitness across the lifespan, and greatly enhances the risk for chronic diseases, as neuropathological disorders, diabetes, cancer and cardiovascular diseases. One of the hallmarks of aging is the loss of proteostasis, a regulated process responsible for maintaining the cellular proteome. When proteostasis is altered, proteome and proteostasis net...
Chestnut honey and bacteriophage application to control Pseudomonas aeruginosa ...
Oliveira, A.; Sousa, Jéssica; Silva, A.; Melo, Luís D. R.; Sillankorva, SannaChronic skin wounds represent a major burn both economically and socially. Pseudomonas aeruginosa and Escherichia coli are among the most common colonizers of infected wounds and are prolific biofilm formers. Biofilms are a major problem in infections due to their increasingly difficult control and eradication, and tolerance to multiple prescribed drugs. As so, alternative methods are necessary. Bacteriophages ...
Evaluation of proteostasis across mammalian lifespan
Martins, Filipa; Francisco, Stephany; Sousa, Jéssica; Pereira, Cátia D.; Correia, Liliana; Camões, Fátima; Soares, Ana Raquel; Rebelo, SandraProteostasis is a highly regulated process involving the proteostasis network responsible for maintaining the cellular proteome. When proteostasis is altered, proteome and proteostasis network disruptions occur, leading to accumulation of protein aggregates, characteristic of several age-related diseases. Previous work performed in Caenorhabditis elegans and zebrafish unveiled asymptomatic protein aggregation (...
Synergistic antimicrobial interaction between honey and phage against Escherich...
Oliveira, A.; Ribeiro, Henrique; Silva, A.; Silva, Maria Daniela; Sousa, Jéssica; Rodrigues, Célia F.; Melo, Luís D. R.; Henriques, Ana FilipaChronic wounds afford a hostile environment of damaged tissues that allow bacterial proliferation and further wound colonization. Escherichia coli is among the most common colonizers of infected wounds and it is a prolific biofilm former. Living in biofilm communities, cells are protected, become more difficult to control and eradicate, and less susceptible to antibiotic therapy. This work presents insights int...