6 documents found, page 1 of 1
Early Mobilization Decision after an Acute Ischemic Stroke: Protocol for an Umb...
Fernandes, C; Sousa, JA; Bernardo-Castro, S; Silva, F; Donato, H; Sargento-Freitas, JIntroduction: Stroke is considered one of the greatest public health challenges worldwide, with the ischemic subtype being the most prevalent. Various acute stroke clinical guidelines recommend early rehabilitation interventions, including very early mobilization. However, despite the studies conducted in recent years regarding when to initiate mobilization after an acute stroke, there are few systematic and pe...
Early Mobilization Decision after an Acute Ischemic Stroke: Protocol for an Umb...
Fernandes, C; Sousa, JA; Bernardo-Castro, S; Silva, F; Donato, H; Sargento-Freitas, JIntroduction: Stroke is considered one of the greatest public health challenges worldwide, with the ischemic subtype being the most prevalent. Various acute stroke clinical guidelines recommend early rehabilitation interventions, including very early mobilization. However, despite the studies conducted in recent years regarding when to initiate mobilization after an acute stroke, there are few systematic and pe...
CTA and CTP for Detecting Distal Medium Vessel Occlusions: A Systematic Review ...
Sousa, JA; Sondermann, A; Bernardo-Castro, S; Varela, R; Donato, H; Sargento-Freitas, JBackground: The optimal imaging method for detecting distal medium vessel occlusions (DMVOs) remains undefined. Purpose: The objective of this study is to compare the diagnostic performance of CTA with CTP in detecting DMVOs. Data sources: We searched PubMed, EMBASE, Web of Science Core Collection, and Cochrane Central Register of Controlled Trials up to March 31, 2023 (PROSPERO: CRD42022344006). Study selectio...
Diagnostic accuracy of CT angiography and CT perfusion imaging for detecting di...
Sousa, JA; Sondermann, A; Bernardo-Castro, S; Varela, R; Donato, H; Sargento-Freitas, JBackground: Distal medium vessel occlusions (DMVOs) represent 25-40% of all acute ischemic strokes (AIS). DMVO clinical syndromes are heterogenous, but as eloquent brain regions are frequently involved, they are often disabling. Since current intravenous fibrinolytic therapies may fail to recanalize up to two-thirds of DMVOs, endovascular treatment is progressively being considered in this setting. Nevertheless...
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke
Bernardo-Castro, S; Albino, I; Barrera-Sandoval, ÁM; Tomatis, F; Sousa, JA; Martins, E; Simões, S; Lino, MM; Ferreira, L; Sargento-Freitas, JStroke represents the second leading cause of mortality and morbidity worldwide. Ischemic strokes are the most prevalent type of stroke, and they are characterized by a series of pathological events prompted by an arterial occlusion that leads to a heterogeneous pathophysiological response through different hemodynamic phases, namely the hyperacute, acute, subacute, and chronic phases. Stroke treatment is highl...
Pathophysiology of Blood–Brain Barrier Permeability Throughout the Different St...
Bernardo-Castro, S; Sousa, JA; Brás, A; Cecília, C; Rodrigues, B; Almendra, L; Machado, C; Santo, G; Silva, F; Ferreira, L; Santana, IThe blood-brain barrier (BBB) is a dynamic interface responsible for maintaining the central nervous system homeostasis. Its unique characteristics allow protecting the brain from unwanted compounds, but its impairment is involved in a vast number of pathological conditions. Disruption of the BBB and increase in its permeability are key in the development of several neurological diseases and have been extensive...