2 documents found, page 1 of 1
A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tubercu...
Bhatt, Kiranmai; Machado, Henrique Pedro Pereira Silva Amaral; Osório, Nuno S.; Sousa, Jeremy; Cardoso, Filipa; Magalhães, Carlos André RodriguesNonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitrile lipopeptides. Orthologous clusters are found in other slow-growing pathogenic mycobacteria ...
Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tub...
Silva, João P.; Gonçalves, Carine; Costa, C.; Sousa, Jeremy; Silva-Gomes, Rita; Castro, António G.; Pedrosa, Jorge; Appelberg, Rui; Gama, F. M.uberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis, recently joined HIV/AIDS on the top rank of deadliest infectious diseases. Low patient compliance due to the expensive, long-lasting and multi-drug standard therapies often results in treatment failure and emergence of multi-drug resistant strains. In this scope, antimicrobial peptides (AMPs) arise as promising candidates for T...