19 documents found, page 1 of 2
Multiple Sclerosis Disease-Modifying Treatment Algorithms: 2025 Positioning of ...
Capela, Carlos; Santos, Ernestina; Palavra, Filipe; Guimarães, Joana; Cerqueira, João; Vale, José; Sousa, Lívia; Batista, Sónia; Sá, Maria JoséMultiple sclerosis (MS) is a chronic autoimmune-mediated neurodegenerative disease characterized by inflammation, demyelination, and axonal/neuronal damage in the central nervous system. In Portugal, the prevalence of MS is approximately 64.4 per 100 000 individuals. It is typically diagnosed in young adults aged 30 to 40, with a higher incidence in women, although it can also affect children/adolescents and th...
Consensus for the Early Identification of Secondary Progressive Multiple Sclero...
Sá, Maria José; Basílio, Carlos; Capela, Carlos; Cerqueira, José João; Mendes, Irene; Morganho, Armando; Correia de Sá, João; Salgado, VascoIntroduction: Multiple sclerosis is a disease with a heterogeneous evolution. The early identification of secondary progressive multiple sclerosis is a clinical challenge, which would benefit from the definition of biomarkers and diagnostic tools applicable in the transition phase from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis. We aimed to reach a Portuguese national con...
Posttranslational modifications of proteins are key features in the identificat...
Salazar, Ivan L.; Lourenço, Ana S. T.; Manadas, Bruno; Baldeiras, Inês; Ferreira, Cláudia; Teixeira, Anabela Claro; Mendes, Vera M.; Novo, Ana MargaridaMultiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the similarity to other inflammatory diseases of the central nervous system, makes it difficult to have a clear diagnosis of multiple sclerosis. Therefore, laboratory tests that allows a clear and definite diagnosis...
Smouldering multiple sclerosis: the 'real MS'
Giovannoni, Gavin; Popescu, Veronica; Wuerfel, Jens; Hellwig, Kerstin; Iacobaeus, Ellen; Jensen, Michael B; García-Domínguez, José Manuel; Sousa, LíviaUsing a philosophical approach or deductive reasoning, we challenge the dominant clinico-radiological worldview that defines multiple sclerosis (MS) as a focal inflammatory disease of the central nervous system (CNS). We provide a range of evidence to argue that the 'real MS' is in fact driven primarily by a smouldering pathological disease process. In natural history studies and clinical trials, relapses and f...
Multiple Sclerosis Patient Management During the COVID-19 Pandemic: Practical R...
Cerqueira, João J.; Ladeira, Ana F.; Martins da Silva, Ana; Timóteo, Ângela; Vale, José; Sousa, Lívia; Arenga, Marta; Abreu, Pedro; Guerreiro, RuiThe spread of the COVID-19 pandemic has imposed significant challenges on healthcare provision, requiring changes in the conventional patient management, particularly in chronic diseases like multiple sclerosis (MS). To increase patient safety and reduce the risk of infection, while ensuring an appropriate and regular follow-up, tele-medicine gained prominence as a valid alternative to face-to-face appointments...
Inflammatory Activity and Treatment Response in Pediatric Compared to Adult Mul...
de Carvalho, Sara; Pinto, Joana; Correia, Inês; Faustino, Ricardo; Vasconcelos, Mónica; Sousa, Lívia; Palavra, FilipeIntroduction: Pediatric-onset multiple sclerosis may contrast with adult-onset multiple sclerosis, in terms of disease activity. We aimed to determine differentiating features between pediatric-onset multiple sclerosis and adult-onset multiple sclerosis, at diagnosis and after one year under disease modifying therapies, and analyse the attainment of the status of “No Evidence of Disease Activity” between groups...
Consenso estratégico nacional para a esclerose múltipla
Lopes, Henrique; Caldas, Alexandre Castro; Silva, Ana Martins; Cerqueira, João; Sá, João de; Santos, José Vale dos; Sousa, Lívia; Sá, Maria JoséO documento que agora se publica resulta do desenvolvimento de um programa de Saúde Pública de grande importância para o país. Reunindo as personalidades e instituições de qualquer forma envolvidas no acompanhamento de doentes sofredores de entidades clínicas particulares, faz-se o retrato completo das necessidades em todas as frentes.O Consenso Estratégico para a Esclerose Múltipla congregou mais de duas dezen...
The epidemiology of multiple sclerosis in the entre Douro e Vouga region of nor...
Branco, Mariana; Alves, Ivânia; Martins da Silva, Ana; Pinheiro, Joaquim; Sá, Maria José; Correia, Inês; Sousa, Lívia; Brandão, Eva; Veira, CarlosBackground: The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north-south gradient of prevalence may be disappearing in the Northern hemisphere. The few previous prevalence studies performed in Portugal have reported a lower prevalence than the average for Western Europe. The aim of this study is to estimate the prevalence of MS in the Entre Douro e Vouga region, in Northern Portug...
[Recommendations about Multiple Sclerosis Management during Pregnancy, Partum a...
Batista, Sónia; Martins da Silva, Ana; Sá, Maria José; Sousa, Lívia; De Sá, João; Pedrosa, Rui; Cerqueira, João; Pinheiro, Joaquim; Abreu, PedroMultiple sclerosis typically affects young women of reproductive age. Therefore, all healthcare professionals involved in the follow-up of multiple sclerosis patients must be prepared to discuss pregnancy and breastfeeding issues and provide the best possible counselling. However, there are still many doubts and heterogeneous clinical approaches partly due to the lack of consensus and guidelines. Concerning the...
Recommendations about Multiple Sclerosis Management during Pregnancy, Partum an...
Batista, Sónia; Martins da Silva, Ana; Sá, Maria José; Sousa, Lívia; de Sá, João; Pedrosa, Rui; Cerqueira, João; Pinheiro, Joaquim; Abreu, PedroMultiple sclerosis typically affects young women of reproductive age. Therefore, all healthcare professionals involved in the follow-up of multiple sclerosis patients must be prepared to discuss pregnancy and breastfeeding issues and provide the best possible counselling. However, there are still many doubts and heterogeneous clinical approaches partly due to the lack of consensus and guidelines. Concerning the...