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Evidence for an association of prenatal exposure to particulate matter with cli...

Santos, João Xavier; Sampaio, Pedro; Rasga, Célia; Martiniano, Hugo; Faria, Clarissa; Café, Cátia; Oliveira, Alexandra; Duque, Frederico

Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants duri...


Deep into the apoplast: grapevine and Plasmopara viticola proteomes reveal the ...

Figueiredo, Joana; Santos, Rita B.; Guerra-Guimarães, Leonor; Leclercq, Céline C.; Renaut, Jenny; Sousa, Lisete; Figueiredo, Andreia

The apoplast is the first hub of plant−pathogen communication where pathogen effectors are recognized by plant defensive proteins and cell receptors, thus activating signal transduction pathways. As a result of this first contact, the host triggers a defense response that involves the modulation of extra- and intracellular proteins. In grapevine−pathogen interactions, little is known about the trafficking betwe...


A Role for Gene-Environment Interactions in Autism Spectrum Disorder Is Support...

Santos, João Xavier; Rasga, Célia; Marques, Ana Rita; Martiniano, Hugo; Asif, Muhammad; Vilela, Joana; Oliveira, Guiomar; Sousa, Lisete; Nunes, Ana

Heritability estimates support the contribution of genetics and the environment to the etiology of Autism Spectrum Disorder (ASD), but a role for gene-environment interactions is insufficiently explored. Genes involved in detoxification pathways and physiological permeability barriers (e.g., blood-brain barrier, placenta and respiratory airways), which regulate the effects of exposure to xenobiotics during earl...


Psychosocial Determinants of Presenteeism at the Workplace in the Pre - COVID-1...

Heitor, Maria João; Dinis, Alexandra; Sousa, Lisete; Moreira, Sérgio; Carreiras, Joana; Ambrósio, Sara; Cooper, Cary; Miguel, José Pereira

Introduction: The impact of organizational stressors on presenteeism at individual and organizational levels, mediated by workers Psychological Wellbeing (PWB) acting as a buffering effect, in the pre-COVID-19 era, is reported. We hypothesize that individual wellbeing is the pathway through which organizational stress affects presenteeism. Methods: A study was conducted between November 2012 and June 2013 and d...


Statistical methods for the study of extracellular vesicles content and their p...

Pestana, Carolina Festas; Sousa, Lisete; Carneiro, Emilie; Barahona, Filipa; Caetano, Joana; Lopes, Raquel; Ferreira, Bruna; João, Cristina


1 ªs Jornadas de Estatística Médica:Programa e Resumos

Diamantino, Fernanda; Sousa, Lisete; Pereira, Miguel; São João, Ricardo; Caldeira, Sílvia; Pereira, Soraia; Domingues, Tiago Dias

O Centro de Estatística e Aplicações (CEAUL) organiza a 1.a edição das Jornadas de Estatística Médica que se realizam nos dias 12 e 13 de fevereiro de 2020. Este encontro destina-se a todos os interessados em aplicações da Estatística nas áreas de Medicina, Enfermagem e Indústria Farmacêutica.


Impact of OVL variation on AUC bias estimated by non-parametric methods

Silva, Carina; Turkman, Maria Antónia Amaral; Sousa, Lisete

The area under the ROC curve (AUC) is the most commonly used index in the ROC methodology to evaluate the performance of a classifier that discriminates between two mutually exclusive conditions. The AUC can admit values between 0.5 and 1, where values close to 1 indicate that the model of classification has high discriminative power. The overlap coefficient (OVL) between two density functions is defined as the...


Validation of the nursing diagnosis of impaired walking in elderly

Marques-Vieira, Cristina; Sousa, Luís; Costa, Débora; Mendes, Cláudia; Sousa, Lisete; Caldeira, Sílvia

Background The increase in longevity causes restriction of activity in the elderly, causing changes on the execution of daily activities and consequently on the quality of life [1]. Walk is an activity that requires using a variety of skills and can be highly complex particularly for the elderly people [2]. The nursing diagnosis impaired walking is part of NANDA International since 1998 and requires further val...


Maternal CNV transmission to sons with autism correlates with phenotypic traits...

Vicente, A.M.; Asif, Muhammad; Conceição, Inês; Kwiatkowska, Katarzyna; Rasga, Celia; Oliveira, Guiomar; Sousa, Lisete; Couto, Francisco

Autism Spectrum Disorder (ASD): Common neurodevelopmental disorder, global prevalence ~1 %; Persistent deficits in social communication and social interaction; restricted and repetitive behavior, interests, or activities – highly heterogeneous clinical presentation; Male to female ratio ~4:1.


Cross-cultural validation of the falls efficacy scale international in elderly:...

Marques-Vieira, Cristina Maria Alves; Sousa, Luís Manuel Mota; Severino, Sandy; Sousa, Lisete; Caldeira, Sílvia

The aim of this study is to describe the psychometric properties of cultural adaptations of the Falls Efficacy Scale International (FES-I) in the elderly dwelling in the community. A systematic literature review was performed according to the research question: What are the psychometric properties of the FES-I in the elderly dwelling in the community in different cultural backgrounds? The Population, Interest, ...


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