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Persistent Proinflammatory Cytokine Profile in the Tear Fluid of Stable Keratoc...
Gil, Pedro; Quadrado Gil, João; Cruz, Nuno; Costa, Celso; Rodrigues-Santos, Paulo; Sousa, Luana Madalena; Almeida, Jani Sofia; Fernandes, RosaPurpose: Keratoconus is traditionally classified as a noninflammatory corneal ectasia, despite growing evidence suggesting an underlying inflammatory component. This study evaluates whether patients with stable keratoconus exhibit persistent inflammatory activity in tear fluid compared to healthy controls. Methods: Cross-sectional case-control study. Keratoconus progression was evaluated using tomographic and c...
Comprehensive Evaluation of Peripheral Immunodynamics in Advanced Non-Small Cel...
Rodrigues-Santos, Paulo; Sousa, Luana Madalena; Almeida, Jani Sofia; Barata, Fernando; Figueiredo, AnaIntroduction: Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has transformed the treatment landscape for advanced non-small cell lung cancer (NSCLC). Despite significant benefits for some patients, durable responses are limited to 20%–30% of cases, necessitating predictive biomarkers for better therapeutic guidance. While tumor-based markers such as PD-L1 expression and tumor mutational burden...
Tumor-Infiltrating Lymphocytes and Cancer Markers in Osteosarcoma: Influence on...
Casanova, José Manuel; Almeida, Jani-Sofia; Reith, John David; Sousa, Luana Madalena; Fonseca, Rúben; Freitas-Tavares, Paulo; Santos-Rosa, ManuelOsteosarcoma (OST) is the most common type of high-grade primary bone tumor, which mainly affects young adults. The current standard of care for OST combines surgical resection with chemotherapy. The clinical outcomes and the current options to treat OST patients are unsatisfactory and novel treatment strategies are needed. The crosstalk between tumor cells and immune cells is essential to the OST microenvironm...
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Imm...
Sousa, Luana Madalena; Almeida, Jani Sofia; Fortes-Andrade, Tânia; Santos Rosa, Manuel; Tavares, Paulo; Casanova, José Manuel; Rodrigues-Santos, PauloSoft Tissue Sarcomas (STS) are a heterogeneous and rare group of tumors. Immune cells, soluble factors, and immune checkpoints are key elements of the complex tumor microenvironment. Monitoring these elements could be used to predict the outcome of the disease, the response to therapy, and lead to the development of new immunotherapeutic approaches. Tumor-infiltrating B cells, Natural Killer (NK) cells, tumor-a...
The Role of Natural Killer Cells in Soft Tissue Sarcoma: Prospects for Immunoth...
Fortes-Andrade, Tânia; Almeida, Jani-Sofia; Sousa, Luana Madalena; Santos-Rosa, Manuel; Freitas-Tavares, Paulo; Casanova, José ManuelSoft-tissue sarcomas (STS) represent about 80% of sarcomas, and are a heterogeneous group of rare and malignant tumors. STS arise from mesenchymal tissues and can grow into structures such as adipose tissue, muscles, nervous tissue and blood vessels. Morphological evaluation has been the standard model for the diagnosis of sarcomas, and even in samples with similar characteristics, they present a diversity in c...