5 documents found, page 1 of 1
SARS-CoV-2 : informações e impactos
Santos, Gardênia Taveira; Araújo, Joabe Lima; Sousa, Lucas Aires de; Passos, Ionara Nayana Gomes; Vieira, Julia Augusto; Cruz, Hugo Vitor MenezesEm Wuhan, China, no final do ano de 2019 ocorreu um surto de pneumonia viral de causa desconhecida, até que em 7 de Janeiro de 2020 foi identificado o agente etiológico desta doença pelo Centro Chinês de Controle e Prevenção de Doenças (CDC), em quese tratava de uma Síndrome Respiratória Aguda Grave por Coronavírus 2(SARS-CoV-2) conhecida como coronavírus 19(COVID-19). Esse vírus já infectou até o dia 01 de jun...
DFT, molecular docking, and ADME/Tox screening investigations of market‑availab...
Araújo, Joabe Lima; Sousa, Lucas Aires de; Sousa, Alice O.; Bastos, Ruan Sousa; Santos, Gardênia Taveira; Lage, Mateus R.; Stoyanov, Stanislav R.A series of drugs was investigated to determine structural, electronic and pharmacological properties, as well as the molecular affinity for the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The drugs were submitted to density functional theory calculations to optimize structures and predict binding preferences. The optimized geometries were used in molecular docking simulations...
Information and impacts generated on society by the novel coronavirus 2019-nCoV...
Santos, Gardênia Taveira; Araújo, Ingryde Lima; Cruz, Hugo Vitor Menezes; Santos, Gabel Taveira; Sousa, Alice de Oliveira; Pinheiro, Ana Maria AlvesSARS-CoV-2 has been affecting the lives of thousands of people around the world, leading to the death of more than 745,000 people. There is still no effective treatment for this disease it leads to chaos in the public health and economy of the affected countries. Thus, this study aimed to collect information regarding SARS-CoV-2, as well as the impacts generated in society by the novel coronavirus. Thus, a pros...
Molecular docking and evaluation of antileishmania activity of a ruthenium comp...
Araújo, Joabe Lima; Bastos, Ruan Sousa; Santos, Gardênia Taveira; Alves, Michel Muálem de Moraes; Figueiredo, Kayo Alves; Sousa, Lucas Aires deLeishmaniasis is an infectious disease that affects both animals and humans, caused by flagellated parasites belonging to the genus Leishmania. The disease is estimated to reach about 700,000 to 1 million people, causing the deaths of 20 to 30,000 individuals annually. Thus, the present study aims to perform molecular docking tests and evaluation of antileishmania activity in vitro of a ruthenium complex with e...
SARS-CoV-2 or Covid-19 : the search for alternative treatment for the new coron...
Araújo, Joabe Lima; Azevedo, Vitória Santos; Araújo, Adrielle de Sá; Araújo, Jessé Lima; Araújo, Ingryde Lima; Sousa, Lucas Aires deSARS-CoV-2 belongs to the Coronaviridae family and of the order Nidovirales, which has positive non-segmented RNA, of the enveloped type that causes a severe acute respiratory syndrome in humans, which has already infected more than 9 million people worldwide, leading to 496,075 deaths by June 27, 2020, making the search for alternative treatment for this pathogen urgent. Thus, this study aimed to conduct a bib...