7 documents found, page 1 of 1
Nanomedicines for the delivery of antimicrobial peptides (AMPs)
Teixeira, Maria C.; Carbone, Claudia; Sousa, Maria C.; Espina, Marta; Garcia, Maria L.; Sanchez-Lopez, Elena; Souto, Eliana B.Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5–100 ...
Lavandula Luisieri and Lavandula Viridis Essential Oils as Upcoming Anti-Protoz...
Machado, Marisa; Martins, Natália; Salgueiro, Lígia; Cavaleiro, Carlos; Sousa, Maria C.Background and objectives: Leishmania species is the causative agent of leishmaniasis, a broad-spectrum clinical condition that can even be life-threatening when neglected. Current therapeutic strategies, despite beings highly cost-e ective, have been increasingly associated with the appearance of drug-resistant microorganisms. Thus, an increasing number of thorough studies are needed towards upcoming drug disc...
Effect of chitosan-Aloe vera coating on postharvest quality of blueberry (Vacci...
Vieira, Jorge M.; Flores-López, M. L.; Jasso de Rodríguez, D.; Sousa, Maria C.; Vicente, A. A.; Martins, JoanaThe present study was carried out to evaluate the effect of chitosan-based edible coatings with Aloe vera extract on the postharvest blueberry fruit quality during storage at 5 °C. Firstly, A. vera fractions (pulp and liquid) were extracted from leaves and evaluated in terms of antifungal and antioxidant capacities. The choice of the most adequate chitosan and A. vera fraction concentrations to be incorporated ...
Antileishmanial Activity of Semisynthetic Lupane Triterpenoids Betulin and Betu...
Sousa, Maria C.; Varandas, Raquel; Santos, Rita C.; Santos-Rosa, Manuel; Alves, Vera; Salvador, Jorge A. R.Leishmaniasis is a neglected tropical disease (NTDs), endemic in 88 countries, affecting more than 12 million people. The treatment consists in pentavalent antimony compounds, amphotericin B, pentamidine and miltefosine, among others. However, these current drugs are limited due to their toxicity, development of biological resistance, length of treatment and high cost. Thus, it is important to continue the sear...
99mTc-MAA for Lung Perfusion Scintigraphy: Impact of Counting Method on the Eff...
Costa, Pedro; Cunha, Lídia; Soares, Sofia; Mendes, Ângela; Queiroz, Ana; Nunes, Amélia; Ferreira, Elisabete; Botelho, Elisa; Sousa, Maria C.: 99mTc-MAA (macroaggregates of albumin) is the selected radiopharmaceutical for the Lung Perfusion Scintigraphy. It is retained in lung capillaries by mechanical blockage resulting in local microembolization. Care should be taken concerning not only particle size but also the number of particles administered to patients, particularly those who present with special conditions (pulmonary hypertension, shunt or l...
Is there a need for attenuation correction in the 99mTc-DMSA scans on pediatric...
Nogueira, Fábio; Lemos, Joana; Oliveira, Marta; Silva, José A.; Sousa, Maria C.; Cunha, Lídia; Metello, Luís F.Introduction: The quantification of th e differential renal function in adults can be difficult due to many factors - on e of the se is the variances in kidney depth and the attenuation related with all the tissue s between the kidney and the camera. Some authors refer that t he lower attenuation i n p ediatric patients makes unnecessary the use of attenuation correction algorithms. This study will com pare the...
Identification and determination of the viability of Giardia lamblia cysts and ...
Lemos, Vanessa; Graczyk, Thaddeus; Alves, Margarida; Lobo, Maria; Sousa, Maria C.; Antunes, Francisco; Matos, OlgaIn the present study, fluorescent in situ hybridization (FISH) and monoclonal antibodies (MAbs) were evaluated for species-specific detection and viability determination of Giardia lamblia, Cryptosporidium parvum, and Cryptosporidium hominis in human fecal and water supply samples. A total of 50 fecal human samples positive for G. lamblia cysts, 38 positive for C. parvum, and 23 positive for C. hominis were stu...