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A natural oxadiazine isolated from cyanobacteria kills cancer cells in multicel...
Sousa, Maria Lígia; Preto, Marco; Martins, Rosário; Vasconcelos, Vítor; Linder, Stig; Urbatzka, RalphCyanobacteria are versatile microorganisms that ubiquitously inhabit terrestrial and aquatic ecosystems. They adapt to external threats by mainly producing secondary metabolites. Therefore, cyanobacteria have been recognized as producer of natural products with potential biotechnological applications, such as bioplastics, antifouling, antibiotics, antiprotozoal or anticancer treatment.
Generation of spheroids of cancer cells for screening of antitumour activity of...
Sousa, Maria Lígia; Preto, Marco; Vasconcelos, Vítor; Martins, Rosário; Linder, Stig; Leão, Pedro; Urbatzka, RalphThe use of 3D cell culture for modelling cancer research is gaining interest, and in particular for screening of bioactive compounds. In the presented work, three compounds isolated from cyanobacteria and 92 chromatographic fractions obtained from crude organic extracts of 28 cyanobacterial strains from the Portuguese coast were tested on multicellular spheroids generated from the human cell lines HCT116 (colon...