9 documents found, page 1 of 1
Developing robust heterotypic 3D lung cancer cultures for drug screening: preli...
Pinto, Bárbara; A. Silva, Patrícia M.; Sarmento, Bruno; Carvalho-Tavares, Juliana; Bousbaa, HassanBackground: To propel advancements in cancer treatment, it is imperative to conduct initial drug testing using in vitro models. In laboratory settings, the efficacy of most compounds is rigorously evaluated through 2D cell cultures. However, many compounds showing promise in these models fail to perform similarly in preclinical or clinical trials, prolonging the timeline for developing effective drugs for human...
Exploring the Clinical Relevance of p31comet in Head and Neck Squamous Cell Car...
Henriques, Ana C. Henriques; Silva , João P. N.; Pinto, Bárbara; Silva, Patricia M. A.; Bousbaa, HassanThe p31comet protein plays a pivotal role in regulating spindle assembly checkpoint silencing and is overexpressed in several cancers, including oral cancer. Despite this, its exact roles in tumorigenesis and its prognostic significance remain unclear. In this study, using the UALCAN cancer database, we analyzed p31comet expression and its correlation with clinical indicators in Head and Neck Squamous Cell Carc...
Implementação e avaliação de percurso didático no Ensino Superior
Jorge, Noémia de Oliveira; Barbosa, Ema; Coutinho, Bárbara; Pinto, BárbaraApresenta-se, neste artigo, uma reflexão sobre pedagogia no enino superior, com enfoque num procedimento didático específico, denominado percurso didático (Jorge, 2019). A reflexão tem como ponto de partida uma experiência de ensino-aprendizagem ocorrida no âmbito de uma unidade curricular de uma licenciatura em Educação Básica, no 1.º semestre do ano letivo de 2022/2023. A experiência assentou na articulação e...
Nanomedicine internalization and penetration: why should we use spheroids?
Pinto, Bárbara; Pacheco, Catarina; Silva, Patrícia; Carvalho-Tavares , Juliana; Sarmento, Bruno; Bousbaa, HassanCancer is a leading cause of death worldwide and, despite medical advances in the development of new anticancer therapies, drug resistance, complicated side effects and poor efficacy remain a major public health problem. To breakdown the antisuppressive tumour strategies and to improve drug efficiency, nanomedicine is increasingly being used in anticancer therapy studies. Different in vitro experimental models ...
A saúde e a segurança do trabalho: o absentismo nos trabalhadores de uma empres...
Pinto, Bárbara; Norelho, Óscar; Oliveira, Ana; Dias, Sofia; Gonçalves, Isabel; Instrumento, Luís; Rua, MaríliaSem resumo disponível.
Study on the ecology and distributional patterns of the epigeous Gasteromycetes...
Louro, Rogério; Calado, Maria; Pinto, Bárbara; Santos-Silva, CelesteThe influence of several environmental and antropic parameters were evaluated on productivity, diversity and distribution patterns of the Gasteromycetes, in Parque de Natureza de Noudar (Alentejo, Portugal). The study area is dominate by holm oak stands with and without shrubs (montado) and areas of pastures and grasses. In a minor scale, there are some cork oak stands, shrub lands and stream margins vegetation...
Tuning iris recognition for noisy images
J. Ferreira, Artur; Lourenço, André Ribeiro; Pinto, Bárbara; Tendeiro, JorgeThe use of iris recognition for human authentication has been spreading in the past years. Daugman has proposed a method for iris recognition, composed by four stages: segmentation, normalization, feature extraction, and matching. In this paper we propose some modifications and extensions to Daugman's method to cope with noisy images. These modifications are proposed after a study of images of CASIA and UBIRIS ...
Epigeous Macrofungi of the Parque de Natureza de Noudar in Alentejo (Portugal)
Santos-Silva, Celeste; Pinto, Bárbara; Calado, Maria; Louro, RogérioThis inventory represents the first list of the epigeous macrofungi collected in Parque de Natureza de Noudar (Barrancos, Alentejo, Portugal). Throughout 3 years 162 taxa were registered, from which 8 are new species for Portugal and 77 for Alentejo. Some of them are considered rare species whereas others have been suggested to acquire a conservation status.
Modifications and Improvements on Iris Recognition
J. Ferreira, Artur; Lourenço, André; Pinto, Bárbara; Tendeiro, JorgeIris recognition is a well-known biometric technique. John Daugman has proposed a method for iris recogni tion, which is divided into four steps: segmentation, normalization, feature extraction and matching. In this paper, we evaluate, modify and extend John Daugman’s method. We study the images of CASIA and UBIRIS databases to establish some modifications and extensions on Daugman’s algorithm. The major modifi...