52 documents found, page 1 of 6
Investigação Clínica da Iniciativa do Investigador em Portugal: Identificação d...
Ferreira, JP; Leite-Moreira, A; Costa-Pereira, A; Soares, AJ; Robalo-Cordeiro, C; Jerónimo, C; Gavina, C; J. Pinto, F; Schmitt, F; Saraiva, F
Total Tumor Load to assist in the decision for additional axillary surgery in t...
Sousa, N; Peleteiro, B; Fougo, JLThe Total Tumor Load (TTL) concept has been demonstrated to accurately predict the status of the non-sentinel lymph nodes (NSLN) in breast cancer patients. In 2019, our center implemented the TTL cut-off of 30,000 CK19 mRNA copies/μL as sole criterion for deciding on performing ALND. This retrospective, unicentric, study analyzed 87 cT1-3N0 breast cancer patients treated consecutively in a period of two years a...
ATENA–A Novel Rapidly Manufactured Medical Invasive Ventilator Designed as a Re...
Rebelo, T; Neutel, E; Alves, EC; Barros, F; Oliveira, H; Machado, H; Mendonça, J; Araújo, JF; Luís, J; Pêgo, JM; Silva, J; Oliveira, M; Sousa, NBackground: The urgent need for mechanical ventilators to support respiratory insufficiency due to SARS-CoV-2 led to a worldwide effort to develop low-cost, easily assembled, and locally manufactured ventilators. The ATENA ventilator project was developed in a community-based approach targeting the development, prototyping, testing, and decentralized manufacturing of a new mechanical ventilator. Objective: This...
Astrocyte-derived TNF and glutamate critically modulate microglia activation by...
Canedo, T; Portugal, CC; Socodato, R; Almeida, TO; Terceiro, AF; Bravo, J; Silva, AI; Magalhães, JD; Guerra-Gomes, S; Oliveira, JF; Sousa, NMethamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational purposes. Besides disrupting the monoaminergic system and promoting oxidative brain damage, Meth also causes neuroinflammation, contributing to synaptic dysfunction and behavioral deficits. Aberrant activation of microglia, the largest myeloid cell population in the brain, is a common feature in neurological disorders tri...
Brain functional connectivity is altered in patients with Takotsubo Syndrome
Silva, AR; Magalhães, R; Arantes, C; Moreira, PS; Rodrigues, M; Marques, P; Marques, J; Sousa, N; Pereira, VHTakotsubo syndrome (TTS) is an acute, reversible cardiomyopathy. The central autonomic nervous system (ANS) is believed to play a role in this disease. The aim of the present study was to investigate the patterns of brain functional connectivity in a sample of patients who had experienced a previous episode of TTS. Brain functional connectivity, both at rest and in response to the stressful stimulus of topical ...
The correlation between serum vascular endothelial growth factor (VEGF) and tum...
Goulart, A; Ferreira, C; Rodrigues, A; Coimbra, B; Sousa, N; Leão, PPURPOSE: Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear. This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC. METHODS: A pro...
High-Intensity Interval Training Versus Moderate-Intensity Continuous Training ...
Mendes, R; Sousa, N; Themudo-Barata, JL; Reis, VMBackground: This study aimed to compare the acute effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on glycemic control in middle-aged and older patients with type 2 diabetes (T2D), using treadmill walking as aerobic exercise mode. Methods: Fifteen patients with T2D (60.25 ± 3.14 years; glycated hemoglobin 7.03 ± 0.33%; medicated with metformin and/or glipti...
WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
Gonçalves, CS; Vieira de Castro, J; Pojo, M; Martins, EP; Queirós, S; Chautard, E; Taipa, R; Pires, MM; Pinto, AA; Pardal, F; Custódia, C; Faria, CCGlioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting a potential therapeutic target, the relevance of WNT6, an activator of this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated in GBM. WNT6 levels were...
Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats
Soares, AR; Esteves, M; Moreira, PS; Cunha, AM; Guimarães, MR; Carvalho, MM; Raposo-Lima, C; Morgado, P; Carvalho, AF; Coimbra, B; Melo, AImpulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the influence of modulating effects. We designed the present study to investigate, in a cohort of sign...
Physical activity and exercise on diabetic foot related outcomes: a systematic ...
Matos, M; Mendes, R; Silva, AB; Sousa, NBackground: Diabetic foot is one of the most common complications of diabetes. It has the potential risk of pathologic consequences including infection, ulceration and amputation, but a growing body of evidence suggests that physical activity and exercise may improve diabetic foot outcomes. Objective: To analyze de effects of exercise and physical activity interventions on diabetic foot outcomes. Methods: A com...