220 documents found, page 1 of 22

Evaluation of P-glycoprotein activity mediated by fiscalin derivatives at the r...

Background: P-glycoprotein (P-gp) is an active efflux pump that reduces xenobiotics’ accumulation inside cells, and which activity can be modulated by inhibitors, inducers and activators [1,2]. The first ones have been used to counteract the multidrug resistance (MDR) phenomena and the inducers and activators have been proposed as a therapeutic approach in intoxication scenarios. In fact, P-gp binds several unr...

Arterio-ureteral fistula: A case-based review of significant hematuria

BACKGROUND: Arterio-ureteral fistula (AUF) is a rare but life-threatening cause of hematuria. Most AUFs are secondary to malignancy or extensive pelvic/ vascular surgery CASE REPORT: A case of an 84-year-old patient who developed significant hematuria 4 months after pelvic surgery due to urothelial carcinoma is presented. CONCLUSION: Active surveillance of patients with predisposing risk factors and sensitivity...

Police officers' aggressivity: how is related to psychological variables and ho...

O inimigo invisível resistente que desafia a indústria alimentar

Natural preservation strategies for fruit: based bakery fillings

The storage stability of an industrial banana-based filling commonly used in bakery applications was evaluated over 70 days at 22 °C and 62% relative humidity. Potassium sorbate (0.095%) was replaced with a commercial red fruit extract (0.5%) as a natural preservative. Microbiological characteristics, including total viable counts, molds and yeasts and spore-forming bacilli, were assessed throughout storage. Ad...

Segurança alimentar em foco: controlo de Listeria monocytogenes em ambientes de...

O objetivo deste documento é informar a indústria alimentar sobre os riscos associados à contami- nação por L. monocytogenes. A presença desta bactéria em produtos acabados ou ambientes de pro- cessamento alimentar representa sérias ameaças à saúde do consumidor e pode levar a consequências económicas significativas. Este manual tem como objetivo alertar a indústria para os riscos recorrentes da contaminação e ...

Breaking the virus: yeast glucans as an effective alternative to acyclovir in H...

Glucans, structural polysaccharides in the yeast cell wall, are known for their biological and immunomodulatory capacities, helping in prevention and management of infections. Herpes simplex virus type 1 (HSVI) is a prevalent infection that causes great comorbidity and is challenging to treat due to the adverse effects of standard antiviral drugs like acyclovir. This study assessed the potential of yeast glucan...

Efficacy and safety of pharmacological treatments in inclusion body myositis: a...

Objective: To identify the best evidence on the efficacy of treatment interventions for inclusion body myositis (IBM) and to describe their safety. Methods: Systematic review of randomised controlled trials (RCTs) of pharmacological treatments of adults with IBM, conducted according to the Cochrane Handbook, updating a previous Cochrane review. The search strategy was run on Cochrane Neuromuscular Disease Group...

Effect of increasing gentamicin concentrations on Listeria monocytogenes cells ...

Introduction: Listeria monocytogenes is a notorious foodborne pathogen responsible for listeriosis, a severe bacterial infection primarily affecting individuals with weakened immune systems, including pregnant women, elderly and other immunocompromised persons. Because of its ability to survive harsh environmental conditions, such as refrigeration temperatures and disinfection processes, it can persist in food ...

Listeria monocytogenes persister cells formation triggered upon antimicrobial e...

Persister cells are a sub-population of growth-arrested bacteria with ability to transiently tolerate bactericidal levels of antimicrobial agents. While they do not replicate in the presence of these agents, they can persist during the exposure and later restore to an active, growing state under favorable conditions. This ability may contribute to the persistence of foodborne pathogens, such as Listeria monocyt...