213 documents found, page 1 of 22

Evaluation of P-glycoprotein activity mediated by fiscalin derivatives at the r...

Background: P-glycoprotein (P-gp) is an active efflux pump that reduces xenobiotics’ accumulation inside cells, and which activity can be modulated by inhibitors, inducers and activators [1,2]. The first ones have been used to counteract the multidrug resistance (MDR) phenomena and the inducers and activators have been proposed as a therapeutic approach in intoxication scenarios. In fact, P-gp binds several unr...

Breaking the virus: yeast glucans as an effective alternative to acyclovir in H...

Glucans, structural polysaccharides in the yeast cell wall, are known for their biological and immunomodulatory capacities, helping in prevention and management of infections. Herpes simplex virus type 1 (HSVI) is a prevalent infection that causes great comorbidity and is challenging to treat due to the adverse effects of standard antiviral drugs like acyclovir. This study assessed the potential of yeast glucan...

Arterio-ureteral fistula: A case-based review of significant hematuria

BACKGROUND: Arterio-ureteral fistula (AUF) is a rare but life-threatening cause of hematuria. Most AUFs are secondary to malignancy or extensive pelvic/ vascular surgery CASE REPORT: A case of an 84-year-old patient who developed significant hematuria 4 months after pelvic surgery due to urothelial carcinoma is presented. CONCLUSION: Active surveillance of patients with predisposing risk factors and sensitivity...

Efficacy and safety of pharmacological treatments in inclusion body myositis: a...

Objective: To identify the best evidence on the efficacy of treatment interventions for inclusion body myositis (IBM) and to describe their safety. Methods: Systematic review of randomised controlled trials (RCTs) of pharmacological treatments of adults with IBM, conducted according to the Cochrane Handbook, updating a previous Cochrane review. The search strategy was run on Cochrane Neuromuscular Disease Group...

Police officers' aggressivity: how is related to psychological variables and ho...

Calciphylaxis: a rare cause of limb ulcer – a case report

BACKGROUND: Calciphylaxis is a rare disease with a poor prognosis predominantly found in end-stage renal disease patients treated with dialysis. This pathology most commonly presents with painful non-healing ulcers, predisposing to high risk of sepsis and death. The authors present a case of bilateral leg ulcers due to calciphylaxis. CASE REPORT: A 40-year-old female patient presented with painful ulcers in bot...

Pseudoaneurysm after partial nephrectomy managed by selective angiographic embo...

INTRODUCTION: Partial nephrectomy is considered the gold standard treatment for many renal tumors when technically feasible. Renal artery pseudoaneurysm and arteriovenous fistulas are rare life-threatening complications that occur more frequently after laparoscopic rather than open partial nephrectomy. CASE REPORT: The authors present a case of a 67-year-old female patient with persistent hematuria due to a ren...

Geophysical characterization of the Cercal Paleozoic structure, Iberian Pyrite ...

ABSTRACT: The Cercal Volcano-Sedimentary Complex (Cercal VSC) structure is the westernmost sector of the Iberian Pyrite Belt (IPB) giant metallogenic province and was explored since Roman times for volcanogenic massive sulphides (VMS) and Fe–Mn (Ba) deposits. However, presently only a single deposit is known, the Salgadinho Cu-Ag-Au stockwork/disseminated deposit. Nevertheless, according to several mining compa...

O uso do debriefing após situações de emergência

Enquadramento: O uso do debriefing representa um papel determinante após situações de emergência, nomeadamente no desenvolvimento teórico/prático dos profissionais de saúde, envolvimento interdisciplinar, mudanças reais no tratamento de paragem cardio-respiratória ou abordagem à via aérea, e na melhoria da qualidade dos cuidados prestados pelos profissionais de saúde que lidam com situações de emergência. Objet...

Circular economyeast: saccharomyces cerevisiae as a sustainable source of gluca...

Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this study focused on the extraction method to isolate and purify water-insoluble glucans from two different Saccharomyces cerevisiae strains: an engineered strain obtained from s...