186 documents found, page 1 of 19
Economic Impact of Surveillance of Head Trauma Patients with Coagulopathy and N...
Ribeiro da Costa, Tiago; Batata, Rodrigo; Oliveira, Susana; Fernandes, Armindo; Sousa, Sérgio; Vaz Silva, Filipe; Sá Pinto, Vasco; Tizziani, MárciaIntroduction: According to the Portuguese clinical guidelines published in 1999, patients with traumatic brain injury and coagulopathies should remain in-hospital for 24 hours for clinical and image surveillance, despite having an admission computed tomography (CT) scan showing no intracranial lesions. Growing evidence suggests this practice is not only void of clinical relevance, but that it can also be potent...
Water infrastructure asset management: A contribution to reducing disruptions i...
Nunes, Eusébio P.; Sousa, Sérgio; Carvalho, João; Rodrigues, Cristina Maria SantosThis chapter covers some key topics for asset management in general and for the administration of water supply and wastewater treatment infrastructure in particular. These infrastructures are public goods with high economic investment and are essential for the provision of basic services to the population and must therefore be managed in a sustainable manner to guarantee a high-quality service in harmony with e...
Quality costs and Industry 4.0: inspection strategy modelling and reviewing
Reis, Angélica Muffato; Dall-Orsoletta, Alaíze; Nunes, Eusébio P.; Costa, Lino; Sousa, SérgioInspection strategy (IS) is a key component impacting quality costs. Although often considered an infexible output of initial quality plans, it may require revisions given the dynamic quality situation of the manufacturing system. It is from this background that the present study aims to model and compare diferent IS based on the cost of quality (CoQ) approach for a case study in the automotive manufacturing in...
ViruScopeDB: a comprehensive multi-omics database for highly infectious viruses
Lima, Ana; Carneiro, João; Sousa, Sérgio; Sá, Vítor; Pratas, Diogo; Sá, Vítor J.Highly infectious viruses such as HIV, Ebola, and SARS-CoV-2 have presented ongoing challenges to global health. Consequently, the optimization of rapid detection tests, including PCR, and the identification of new therapeutic targets remain of paramount importance. The development of genomic and proteomic databases like the HIV Oligonucleotide Database (HIVoligoDB) [1], EbolaID [2], and CoV2ID [3] has facilita...
Advancing circular nutrition: the development of a freeze-dried snack based on ...
Soares, Inês; Machado, Daniela; Vedor, Rita; Sousa, Sérgio; Orvalho, Telma; Dias, Sara; Alves, Marco; Gomes, Ana MariaAim: The upcycling of agri-food by-products presents a sustainable strategy for reducing waste and creating value-added products. This study aimed to develop a freeze-dried snack incorporating broccoli stalks, an often discarded by-product, and to characterise its nutritional composition, microbiological quality, physicochemical properties and bioactive potential. Method: Broccoli stalks were freeze-dried, mill...
Breaking the silica barrier: optimising carotenoid extraction from diatoms
Rocha, Helena R.; Coelho, Marta; Sousa, Sérgio; Morais, Rui M. S. C.; Pintado, Manuela; Gomes, Ana M.Introduction: Diatoms are microalgae rich in bioactive carotenoids with antioxidant and health-promoting potential (1,2,3,4). However, their rigid silica frustules limit solvent penetration, hindering efficient carotenoid extraction and concealing their true content (5). This study investigates physical and chemical treatments to disrupt the silica structure of Chaetoceros calcitrans, Nannofrustulum shiloi, and...
Encapsulation of Akkermansia muciniphila in calcium-alginate matrix: a live bio...
Machado, Daniela; Vedor, Rita; Fonseca, Mariana; Sousa, Sérgio; Barbosa, Joana Cristina; Carvalho, Nelson Mota de; Costa, Célia MariaObjective: Akkermansia muciniphila is a next-generation probiotic recognized for improving gut barrier function and metabolic health. However, ensuring its viability during processing, storage, and gastrointestinal transit remains a challenge. This study investigated calcium-alginate encapsulation as a strategy for enhancing the stability of A. muciniphila during refrigerated aerobic storage and gastrointestina...
Microwave hydrodiffusion and gravity: a green extraction technology for phenyle...
Sousa, Ana Sofia; Sousa, Sérgio; Silva, Inês V.; Reis, Celso A.; Coscueta, Ezequiel R.; Pintado, Maria ManuelaWatercress is a cruciferous vegetable and the primary natural source of phenylethyl isothiocyanate (PEITC), a powerful health-promoting agent. Conventional extraction of PEITC relies on harmful solvents, which limits sustainability. This study introduces a novel, solvent-free method—microwave hydrodiffusion and gravity (MHG)—to extract PEITC from watercress by-products (WCBP). Results showed that freezing WCBP ...
Mucopolissacaridoses em população pediátrica: resultados de uma abordagem de pr...
Gaspar, Paulo; Neiva, Raquel; Silva, Lisbeth; Diogo, Luísa; Ferreira, Ana Cristina; Miranda, Ana M.; Antunes, Diana; Louro, Pedro; Ribeiro, SaraAs Mucopolissacaridoses (MPSs), constituem um subgrupo das Doenças Lisossomais de Sobrecarga, causadas por deficiências em enzimas lisos somais, que catalisam a degradação dos glicosaminoglicanos. As MPSs têm apresentação multissistémica, heterogénea e consequentemente de diagnóstico difícil. O projeto FIND tem como objetivo alertar os clínicos para sinais e sintomas de risco ao mesmo tempo que disponibiliza um...
Dashboard development for the quality department of a company from the automoti...
Mateus, Mariana; Sousa, SérgioThe digitalisation of the automotive industry has led to an increase in the volume of data, making it difficult to analyse and interpret. To address this situation, managers have turned to dashboards that provide quick access to relevant information to support decision making. This study focuses on the development of a dashboard for the quality department of a company from the automotive industry. Through data ...