16 documents found, page 1 of 2
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-v...
Reina-Couto, M; Alves, D; Silva-Pereira, C; Pereira-Terra, P; Martins, S; Bessa, J; Teixeira-Santos, L; Pinho, D; Morato, M; Dias, CC; Sarmento, A"Background and aims: Endocan has been scarcely explored in COVID-19, especially regarding its modulation by veno-venous extracorporeal membrane oxygenation (VV-ECMO), hypertension or previous renin-angiotensin-aldosterone system (RAAS) inhibitors treatment. We compared endocan and other endotheliitis markers in hospitalized COVID-19 patients and assessed their modulation by VV-ECMO, hypertension and previous R...
Gender-related differences in cardiometabolic risk factors and oxidative stress...
Godinho, N; Morato, M; Albino-Teixeira, A; Afonso, AC; Sousa, T; Correia-Costa, L"Objectives Gender-related differences in oxidative stress, nitric oxide bioavailability, and cardiometabolic risk factors were examined in a cross-sectional study involving 313 prepubertal children (8–9 years old) from the generation XXI birth-cohort. Methods Anthropometric measurements, cardiometabolic variables, and redox markers were assessed, including plasma and urinary isoprostanes (P-Isop, U-Isop), plas...
Association between blood pressure and angiotensin-converting enzymes activity ...
Gaspar, AR; Andrade, B; Mosca, S; Ferreira-Duarte, M; Teixeira, A; Cosme, D; Albino-Teixeira, A; Ronchi, FA; Leite, AP; Casarini, DE; Areias, JCObjectives:Angiotensin-converting enzymes' (ACEs) relationship with blood pressure (BP) during childhood has not been clearly established. We aimed to compare ACE and ACE2 activities between BMI groups in a sample of prepubertal children, and to characterize the association between these enzymes' activities and BP.Methods:Cross-sectional study of 313 children aged 8-9 years old, included in the birth cohort Gen...
The pro-resolving lipid mediator Maresin 1 ameliorates pain responses and neuro...
Teixeira-Santos, L; Martins, S; Sousa, T; Albino-Teixeira, A; Pinho, DSpecialized pro-resolving mediators (SPMs) have recently emerged as promising therapeutic approaches for neuropathic pain (NP). We evaluated the effects of oral treatment with the SPM Maresin 1 (MaR1) on behavioral pain responses and spinal neuroinflammation in male and female C57BL/6J mice with spared nerve injury (SNI)-induced NP. MaR1, or vehicle, was administered once daily, on post-surgical days 3 to 5, by...
Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and puta...
Reina-Couto, M; Roboredo-Madeira, M; Pereira-Terra, P; Silva-Pereira, C; Martins, S; Teixeira-Santos, L; Pinho, D; Dias, A; Cordeiro, G; Dias, CCBackground Cysteinyl leukotrienes (CysLT) are potent inflammation-promoting mediators, but remain scarcely explored in COVID-19. We evaluated urinary CysLT (U-CysLT) relationship with disease severity and their usefulness for prognostication in hospitalized COVID-19 patients. The impact on U-CysLT of veno-venous extracorporeal membrane oxygenation (VV-ECMO) and of comorbidities such as hypertension and obesity ...
Effects of NADPH Oxidase Isoform-2 (NOX2) Inhibition on Behavioral Responses an...
Teixeira-Santos, L; Veríssimo, E; Martins, S; Sousa, T; Albino-Teixeira, A; Pinho, DNADPH oxidase isoform-2 (NOX2) has been implicated in the pathophysiology of neuropathic pain (NP), mostly through the modulation of neuroinflammation. Since it is also accepted that some neuroimmune mechanisms underlying NP are sex-dependent, we aimed to evaluate the effects of early systemic treatment with the NOX2-selective inhibitor (NOX2i) GSK2795039 on behavioral responses and spinal neuroinflammation in ...
Proinflammatory and endothelial activation profiles in hospitalized COVID-19 pa...
Silva-Pereira, PDC; Reina-Couto, M; Alves, D; Pereira-Terra, P; Martins, S; Bessa, J; Teixeira-Santos, L; Pinho, D; Morato, M; Sarmento, A; Tavares, Mn/a
Urinary Cysteinyl Leukotrienes as Biomarkers of Endothelial Activation, Inflamm...
Reina-Couto, M; Santos-Oliveira, M; Pereira-Terra, P; Silva-Pereira, C; Quelhas-Santos, J; Duarte, Á; Martins, S; Serrão, P; Dias, CC; Morato, MCysteinyl leukotrienes (CysLT) are potent vascular leakage-promoting agents but have been scarcely explored in human septic shock (SS). We evaluated CysLT at admission and during hospitalization and their correlation with endothelial dysfunction, inflammation, oxidative stress, the renin–angiotensin–aldosterone system, and cardiac, renal, respiratory, and hepatic parameters in SS patients. Blood and spot-urine ...
Impact of physical activity on redox status and nitric oxide bioavailability in...
Leite-Almeida, L; Morato, M; Cosme, D; Afonso, J; Areias, JC; Guerra, A; Caldas, Afonso, A; Albino-Teixeira, A; Sousa, T; Correia-Costa, LNutritional status might contribute to variations induced by physical activity (PA) in redox status biomarkers. We investigated the influence of PA on redox status and nitric oxide (NO) production/metabolism biomarkers in nonoverweight and overweight/obese prepubertal children. We performed a cross-sectional evaluation of 313 children aged 8-9 years (163 nonoverweight, 150 overweight/obese) followed since birth...
Dna-based detection of mycobacterium avium subsp. Paratuberculosis in domestic ...
Sousa, T; Costa, M; Sarmento, P; Manso, MC; Abreu, C; Bull, TJ; Cabeda, J; Sarmento, AMycobacterium avium subsp. paratuberculosis (MAP) may play a role in the pathology of human inflammatory bowel disease (IBD). Previously, we found a high frequency (98% in patients with active disease) of MAP DNA detection in the blood of Portuguese Crohn s Disease patients, suggesting this cohort has high exposure to MAP organisms. Water is an important route for MAP dissemination, in this study we therefore a...