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Ionic liquid-based nanoemulsion as a promising strategy to enhance the bioacces...

Sousa, Vítor; Lüdtke, Fernanda Luisa; Hijo, Ariel A. C. Toledo; Loureiro, Luís; Dias, Oscar; Vicente, A. A.; Pinheiro, A. C.; Geada, Pedro

Dunaliella salina is a unicellular halophile green microalga that presents the capacity to accumulate high amounts of β-carotene, a bioactive compound widely recognized by its health benefits. To fulfil its biological functions, however, β-carotene needs to be bioaccessible, which is challenging as its bioaccessibility is typically low. A promising strategy to overcome β-carotene's low bioaccessibility is its e...


Vigilância a Longo Prazo na Gestão do Cancro da Próstata: Factos e Armadilhas

Silva, Tiago; Mateus-Pinheiro, António; Sousa, Vítor; Moreira, Sónia; Santos, Lèlita


Newborn Epiphysiolysis of the Proximal Humerus

Cunha, Mafalda; Silva, Marco Francisco; Sousa, Vítor; Melo, Bruna; Costa, Helena Reis; Azevedo, Maria João

Musculoskeletal injuries resulting from childbirth trauma, including humeral head epiphysiolysis, are rare. This case report describes the clinical presentation, diagnostic evaluation, treatment, and mid-term follow-up of a premature male newborn with humeral head epiphysiolysis due to birth trauma. The infant exhibited limited left shoulder mobility and internal rotation preference. An ultrasound confirmed epi...


Análise do Movimento Assistencial da Comunidade Terapêutica Ponte da Pedra - Es...

Tinoco, Rui; Valinho, Rita; Braga, Ana Sofia; Coutinho, Cátia; Sousa, Vítor

Este estudo teve como objetivo analisar os resultados obtidos a partir da caracterização sociodemográfica das pessoas acolhidas / internadas na Comunidade Terapêutica Ponte da Pedra, no período compreendido entre 2016 e 2022, assim como identificar fatores que possam estar relacionados com a atribuição de altas não clinicas e duração do tratamento. De referir que entre 2016 e 2022 foram registados 328 utentes /...


Towards a genome-scale metabolic model of Dunaliella salina

Cunha, Emanuel Rodrigues; Sousa, Vítor; Vicente, A. A.; Geada, Pedro Miguel Macedo; Dias, Oscar

Dunaliella salina is a green algae known for its ability to produce carotenoids. However, maximizing its production while achieving significant biomass yields remains challenging, which can be addressed through systems biology tools like genome-scale metabolic models. This work presents the first genome-scale metabolic model for D. salina, enabling an in silico analysis and optimization of -carotene and lutein ...


Recovery and encapsulation of Dunaliella salina -carotene through a novel susta...

Sousa, Vítor; Hijo, Ariel A. C. Toledo; Lüdtke, Fernanda Luisa; Vicente, A. A.; Dias, Oscar; Geada, Pedro Miguel Macedo

Dunaliella salina is a promising source of -carotene, widely employed in the food industry. This study aimed to evaluate the sequential application of the Ionic Liquid (IL) cholinium oleate as an extraction solvent for D. salina -carotene recovery and, sequentially, as emulsifier for emulsion-based products obtained therefrom. The IL was evaluated regarding its ability to permeabilize the cells and recover -car...


Differences in trapezius muscle h-reflex between asymptomatic subjects and symp...

Melo, Ana; Taylor, Janet L.; Ferreira, Ricardo; CUNHA, BRUNO; Ascenção, Manuel; Sousa, Vítor; Cruz, Eduardo B.; Vilas-Boas, J. Paulo

In chronic shoulder pain, adaptations in the nervous system such as in motoneuron excitability, could contribute to impairments in scapular muscles, perpetuation and recurrence of pain and reduced improvements during rehabilitation. The present cross-sectional study aims to compare trapezius neural excitability between symptomatic and asymptomatic subjects. In 12 participants with chronic shoulder pain (symptom...


Microalgae biomass as an alternative source of biocompounds: New insights and f...

Sousa, Vítor; Pereira, Ricardo Nuno Correia; Vicente, A. A.; Dias, Oscar; Geada, Pedro

Microalgae have characteristics that make them unique and full of potential. Their capacity to generate interesting bioactive molecules can add value to various industrial applications. However, most of these valuable compounds are intracellular, which makes their extraction a major bottleneck. Conventional extraction methodologies have some drawbacks, such as low eco-friendly character, high costs and energy d...


Systems biology's role in leveraging microalgal biomass potential: Current stat...

Cunha, Emanuel; Sousa, Vítor; Geada, Pedro; Teixeira, J. A.; Vicente, A. A.; Dias, Oscar

Microalgae are an eco-friendly and alternative source of several compounds that can be applied in numerous biotechnological branches such as cosmetics, food, or pharmaceutical industries. However, the commercialization of products from microalgae has still some drawbacks, among which it is possible to highlight the low biomass and compounds' productivities at industrial level. The common strategies to improve t...


Building a Portuguese Coalition for Biodiversity Genomics

Marques, João Pedro; ALVES, Paulo C; Rosário, Isabel Amorim do; Lopes, Ricardo J.; Moura, Mónica; Meyers, Gene; Sim-Sim, Manuela; Sousa-Santos, C.

The diverse physiography of the Portuguese land and marine territory, spanning from continental Europe to the Atlantic archipelagos, has made it an important repository of biodiversity throughout the Pleistocene glacial cycles, leading to a remarkable diversity of species and ecosystems. This rich biodiversity is under threat from anthropogenic drivers, such as climate change, invasive species, land use changes...


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