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Mutation screening in the genes PAX-8, NKX2-5, TSH-R, HES-1 in cohort of 63 Bra...

Cerqueira,Taíse Lima de Oliveira; Ramos,Yanne Rocha; Strappa,Giorgia Bruna; Jesus,Mariana Souza de; Santos,Jailciele Gonzaga; Sousa,Camila

ABSTRACT Objective: To evaluate the candidate genes PAX-8, NKX2-5, TSH-R and HES-1 in 63 confirmed cases of thyroid dysgenesis. Subjects and methods: Characterization of patients with congenital hypothyroidism into specific subtypes of thyroid dysgenesis with hormone levels (TT4 and TSH), thyroid ultrasound and scintigraphy. DNA was extracted from peripheral blood leukocytes and the genetic analysis was realize...

Date: 2018   |   Origin: Oasisbr
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