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Effect of preconditioning and postoperative hyperbaric oxygen therapy on coloni...
Fontoura-Andrade,José Luiz; Pinto,Leonardo Mendes; Carneiro,Fabiana Pirani; Sousa,João Batista deAbstract Purpose To investigate the effect of hyperbaric oxygen therapy on colonic anastomosis healing with and without ischemia in rats. Methods Forty female rats underwent segmental resection of 1 cm of the left colon followed by end-to-end anastomosis. They were randomly assigned to four groups (n=10 each), a sham group; two groups were submitted to Hyperbaric Oxygen therapy (HBOT) with and without induced i...
Does CO2 pneumoperitoneum in laparoscopy interfere with collagen deposition in ...
Morais,Pedro Henrique Alves de; Silva,Rafael Francisco Alves; Ribeiro,Thiago da Silva; Farias,Igor Eduardo Caetano de; Lino Junior,Ruy de SouzaAbstract Purpose To determine by histomorphometric analysis whether CO2 pneumoperitoneum interferes with collagen deposition in surgical wounds in the aponeurosis of rats. Methods This experiment involved 80 male Wistar rats, randomly allocated into four groups according to pneumoperitoneum period (PRE: 30 min preoperatively; POST: 30 min postoperatively; PP: 30 min pre- and postoperatively; C: control group). ...
Improving reproducibility and external validity. The role of standardization an...
Fontoura-Andrade,José Luiz; Amorim,Rivadávio Fernandes Batista de; Sousa,João Batista deAbstract Purpose: To identify the most relevant flaws in standardization in husbandry practices and lack of transparency to report them. This review proposes some measures in order to improve transparency, reproducibility and eventually external validity in experimental surgery experiments with rat model. Methods: We performed a search of scientific articles in PUBMED data base. The survey was conducted from au...
Effect of Hevea brasiliensis latex sap gel on healing of acute skin wounds indu...
Penhavel,Maria Vitória Carmo; Tavares,Victor Henrique; Carneiro,Fabiana Pirani; Sousa,João Batista deObjective : to evaluate the effect of topical delivery of latex cream-gel in acute cutaneous wounds induced on the back of rats. Methods : we subjected sixteen rats to dermo-epidermal excision of a round dorsal skin flap, with 2.5cm diameter. We divided the animals into two groups: Latex Group: application of cream-gel-based latex throughout the wound bed on postoperative days zero, three, six and nine; Control...
Effect of glutamine supplementation on left colon healing in rats with extrahep...
Alecrim,Hugo Muscelli; Duarte,Sérgio Andurte Carvalho; Amaral,Maria Eduarda Bonavides; Diógenis,Filipe; Carneiro,Fabiana Pirani; Sousa,João Batista dePURPOSE:To evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats.METHODS: Sixteen male rats were allocated across four groups: LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on pos...
Effects of metoclopramide on the expression of metalloproteinases and interleuk...
Silva,Silvana Marques e; Jerônimo,Márcio Sousa; Silva-Pereira,Ildinete da; Tavares,Aldo Henrique; Bocca,Anamélia Lorenzetti; Sousa,João Batista dePURPOSE : To evaluate the effects of metoclopramide on metalloproteinases (MMP) and interleukins (IL) gene expression in colonic anastomoses in rats. METHODS : Eighty rats were divided into two groups for euthanasia on the 3rd or 7th postoperative day (POD), then into two subgroups for sepsis induction or not, and then into subgroups to receive either metoclopramide or saline solution. Left colonic anastomosis ...
Effect of vitamin K1 supplementation on left colon healing in rats with extrahe...
Amaral,Maria Eduarda Bonavides; Alecrim,Hugo Muscelli; Duarte,Sérgio Andurte Carvalho; Diógenis,Filipe; Carneiro,Fabiana Pirani; Sousa,João Batista dePURPOSE:To evaluate the effects of vitamin K1 on wound healing in the left colon of rats with experimental biliary obstruction.METHODS: Sixteen male rats, divided into four groups of four animals each (L, M, LK, and MK), underwent colostomy followed by bowel suture in the left colon. Seven days before, animals in the L and LK groups had undergone common bile duct ligation. The animals in groups MK and LK receiv...
A new proposal for laparoscopic left colectomy in a rat model
Durães,Leonardo de Castro; Durães,Eliana Ferreira Ribeiro; Freitas,Pedro Felipe Silva de; Carvalho,Felipe Augusto Neves Oliveira dePURPOSE: To evaluate the feasibility and safety of a new technique for laparoscopic segmental colectomy and primary anastomosis in the left colon of rats. METHODS: Thirty rats were randomly assigned to three groups of ten animals each. All animals underwent segmental resection of the left colon and end-to-end anastomosis. In Group I, the animals underwent laparoscopic surgery with carbon dioxide pneumoperitoneu...
Effects of carbon dioxide therapy on the healing of acute skin wounds induced o...
Penhavel,Maria Vitória Carmo; Nascimento,Victor Henrique Tavares; Durães,Eliana Ferreira Ribeiro; Carneiro,Fabiana Pirani; Sousa,João Batista dePURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; con...
Correlation between bursting pressure and breaking strength in colonic anastomosis
Durães,Leonardo de Castro; Durães,Eliana Ferreira Ribeiro; Lobato,Luiz Felipe de Campos; Oliveira,Paulo Gonçalves de; Sousa,João Batista dePURPOSE: To investigate the correlation between bursting pressure and breaking strength on the 7th postoperative day following left colonic anastomosis in rats. METHODS: Seventy rats were randomly divided into seven groups of ten animals each. All of the animals underwent segmental resection of the left colon and end-to-end anastomosis. The animals in groups I to VI underwent surgical laparoscopies with pneumop...