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Dual-action breakthrough: Fiscalin derivatives targeting amyloid burden and ace...

Background: Alzheimer’s disease (AD) is the most common age-related dementia, characterized by neurodegeneration associated with the accumulation of amyloid-beta (Aβ) peptides and hyperphosphorylated Tau, mitochondrial dysfunction, and oxidative stress, among other pathological features [1]. Moreover, reduced acetylcholine levels contribute to the cognitive impairment and memory deficits characteristic of the d...