5 documents found, page 1 of 1
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...
Coelho, Margarida; Patarrão, Rita S.; Sousa-Lima, Inês; Ribeiro, Rogério César de Almeida; Meneses, Maria João; Andrade, Rita; Mendes, Vera M.Coffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...
Coelho, Margarida; Patarrão, Rita S.; Sousa-Lima, Inês; Ribeiro, Rogério T.; Meneses, Maria João; Andrade, Rita; Mendes, Vera M.; Manadas, BrunoCoffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...
Big data and machine learning to tackle diabetes management
Pina, Ana F; Meneses, Maria João; Sousa-Lima, Inês; Henriques, Roberto; Raposo, João F; Macedo, Maria PaulaType 2 Diabetes (T2D) diagnosis is based solely on glycaemia, even though it is an endpoint of numerous dysmetabolic pathways. Type 2 Diabetes complexity is challenging in a real-world scenario; thus, dissecting T2D heterogeneity is a priority. Cluster analysis, which identifies natural clusters within multidimensional data based on similarity measures, poses a promising tool to unravel Diabetes complexity.
Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases
Sousa-Lima, Inês; Kim, Hyun Jeong; Jones, John; Kim, Young-BumNonalcoholic fatty liver disease (NAFLD) is a major public health problem and the most common form of chronic liver disease, affecting 25% of the global population. Although NAFLD is closely linked with obesity, insulin resistance, and type 2 diabetes mellitus, knowledge on its pathogenesis remains incomplete. Emerging data have underscored the importance of Rho-kinase (Rho-associated coiled-coil-containing kin...
Mutant A53T α-synuclein improves rotarod performance before motor deficits and ...
Guerreiro, Patrícia; Coelho, Joana E; Sousa-Lima, Inês; Macedo, Paula; Lopes, Luisa V.; Outeiro, Tiago; Faria Pais, TeresaThe protein α-synuclein (α-Syn) interferes with glucose and lipid uptake and also activates innate immune cells. However, it remains unclear whether α-Syn or its familial mutant forms contribute to metabolic alterations and inflammation in synucleinopathies, such as Parkinson's disease (PD). Here, we address this issue in transgenic mice for the mutant A53T human α-Syn (α-SynA53T), a mouse model of synucleinopa...