9 documents found, page 1 of 1
Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading ...
Fernandes, AR; Sanchez-Lopez, E; Santini, A; Santos, T; Garcia, ML; Silva, AM; Souto, EBOil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, ...
Development and characterization of nanoemulsions for ophthalmic applications: ...
Fernandes, AR; Sanchez-Lopez, E; Santos, T; Garcia, ML; Silva, AM; Souto, EBThe eye is a very complex organ comprising several physiological and physical barriers that compromise drug absorption into deeper layers. Nanoemulsions are promising delivery systems to be used in ocular drug delivery due to their innumerous advantages, such as high retention time onto the site of application and the modified release profile of loaded drugs, thereby contributing to increasing the bioavailabili...
Dabco-customized nanoemulsions: Characterization, cell viability and genotoxici...
Fernandes, AR; Santos, T; Granja, PL; Sanchez-Lopez, E; Santini, A; Garcia, ML; Silva, AM; Souto, EBQuaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and of quinuclidine surfactants were used to develop oil-in-water nanoemulsions with the purpose of selecting the best long-term stable nanoemulsion for the ocular administration of triamcinolone acetonide (TA). The combination of the best physicochemical properties (i.e., mean droplet size, polydispersity index, zeta potential, osmolality, viscoel...
The therapeutic potential of Apigenin
Salehi, B; Venditti, A; Sharifi-Rad, M; Kregiel, D; Sharifi-Rad, J; Durazzo, A; Lucarini, M; Santini, A; Souto, EB; Novellino, E; Antolak, H; Azzini, ESeveral plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo ...
Linseed essential oil - Source of Lipids as Active Ingredients for Pharmaceutic...
Campos, J; Severino, P; Ferreira, C; Zielinska, A; Santini, A; Souto, S; Souto, EBLinseed - also known as flaxseed -, is known for its beneficial effects on animal health attributed to its composition, comprising omega-6 (linoleic) and omega-3 (α-linolenic) fatty acids, various dietary fibers and lignans, which have health benefits in reducing the risk of cancer and cardiovascular diseases, lowering the levels of LDL-cholesterol and relaxing the smooth muscle cells in arteries increasing the...
Design of cationic lipid nanoparticles for ocular delivery: Development, charac...
Fangueiro, JF; Andreani, T; Egea, MA; Garcia, ML; Souto, SB; Silva, AM; Souto, EBIn the present study we have developed lipid nanoparticle (LN) dispersions based on a multiple emulsion technique for encapsulation of hydrophilic drugs or/and proteins by a full factorial design. In order to increase ocular retention time and mucoadhesion by electrostatic attraction, a cationic lipid, namely cetyltrimethylammonium bromide (CTAB), was added in the lipid matrix of the optimal LN dispersion obtai...
Evaluation of the physical stability of SLN and NLC before and after incorporat...
Souto, EB; Wissing, SA; Barbosa, CM; Muller, RHAqueous dispersions of lipid nanoparticles are being investigated as drug delivery systems for different therapeutic purposes. One of their interesting features is the possibility of topical use, for which these systems have to be incorporated into commonly used dermal carriers, such as creams or hydrogels, in order to have a proper semisolid consistency. For the present investigation four different gel-forming...
Development of a controlled release formulation based on SLN and NLC for topica...
Souto, EB; Wissing, SA; Barbosa, CM; Muller, RHSolid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many Substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles, as well as the entrapment efficiency of this lipophilic drug and its in vitro release profile...
Comparative study between the viscoelastic behaviors of different lipid nanopar...
Souto, EB; Wissing, SA; Barbosa, CM; Muller, RHApplication of drug substances to the skin for systemic absorption or action in a particular layer of the skin is a rather old approach. However, over the last years it has received much more attention, as a consequence of the development of new membrane-moderated and matrix reservoir devices. As new reservoir systems, solid lipid nanoparticles (SLN(TM)) and nanostructured lipid carriers (NLC(TM)) have been suc...