4 documents found, page 1 of 1
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles...
Favaro-Trindade, Carmen S.; Matos Junior, Fernando E. de; Okuro, Paula K.; Dias-Ferreira, João; Cano, Amanda; Severino, Patricia; Zielińska, AleksandraNanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solve...
Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharma...
Souto, Eliana; Macedo, Ana S; Dias-Ferreira, João; Cano, Amanda; Zielińska, Aleksandra; Matos, Carla M.Administration of active pharmaceutical ingredients (APIs) through the skin, by means of topical drug delivery systems, is an advanced therapeutic approach. As the skin is the largest organ of the human body, primarily acting as a natural protective barrier against permeation of xenobiotics, specific strategies to overcome this barrier are needed. Liposomes are nanometric-sized delivery systems composed of phos...
Surface engineering of silica nanoparticles for oral insulin delivery: characte...
Andreani, Tatiana; Kiill, Charlene P.; Souza, Ana Luiza R. de; Fangueiro, Joana F.; Fernandes, Lisete; Doktorovová, Slavomira; Santos, Dario L.The present work aimed at studying the interaction between insulin and SiNP surfaced with mucoadhesive polymers (chitosan, sodium alginate or polyethylene glycol) and the evaluation of their biocompatibility with HepG2 and Caco-2 cell lines, which mimic in vivo the target of insulin-loaded nanoparticles upon oral administration. Thus, a systematic physicochemical study of the surface-modified insulin-silica nan...