275 documents found, page 1 of 28
Modified drug delivery systems for veterinary use: pharmaceutical development a...
Souto, Eliana B.; Barbosa, Catarina I.; Baldim, Iara; Campos, Joana R.; Fernandes, Ana R.; Mazzola, Priscila G.; Andreani, Tatiana; Dias, Isabel R.Scientific research in the field of veterinary pharmacology has provided new opportunities for the development of modified release dosage forms, with the aim to improve therapeutic efficacy and reduce animal stress. The formulation of classical drug molecules with advanced biomaterials has become a new approach to increasing drug bioavailability and improving the therapeutic outcome. The main reasons for the de...
Correction: Jose et al. Transferrin-Conjugated Docetaxel–PLGA Nanoparticles for...
Jose, Sajan; Cinu, Thomas A.; Sebastian, Rosmy; Shoja, M. H.; Aleykutty, N. A.; Durazzo, Alessandra; Lucarini, Massimo; Santini, AntonelloIn the original publication [...]
Fermented food/beverage and health: current perspectives
Durazzo, Alessandra; Carocho, Márcio; Heleno, Sandrina A.; Pedrosa, Mariana C.; Ueda, Jonata Massao; Barros, Lillian; Souto, Eliana B.Fermented products have been gaining a notable importance in recent years due to the health benefits that they can provide in relation to the initial unfermented food matrix, i.e. in the enhancement of nutrients, effect on glucose metabolism and bioactivity, the presence of probiotics in some foods. The paper gives a current analysis of the fermented food/beverage and health relationship studies present in the ...
Biodegradable nanoparticles for the treatment of epilepsy: From current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
Correction: Diniz et al. Silver Nanoparticles-Composing Alginate/Gelatine Hydro...
Diniz, Flavia Resende; Maia, Romerito Cesar A. P.; de Andrade, Lucas Rannier M.; Andrade, Luciana Nalone; Vinicius Chaud, MarcoIn the original publication, there was a mistake in Figure 6 as published [...]
Lycopene: total-scale literature landscape analysis of a valuable nutraceutical...
Yeung, Andy Wai Kan; Choudhary, Neeraj; Tewari, Devesh; El-Demerdash, Amr; Tomczyk, Michal; Das, Niranjan; Pirgozliev, Vasil; Lucarini, MassimoLycopene intake from tomatoes and other food sources has multiple potential health benefits. This report aimed to evaluate the current research literature on lycopene concerning human and animal health. The electronic Web of Science Core Collection database was searched with (lycopene*) AND (health* OR illness* OR disease* OR medic* OR pharma* OR drug* OR therap*). The resulted 3972 papers were analyzed with th...
Lipid nanoparticles for the posterior eye segment
Bonilla, Lorena; Espina, Marta; Severino, Patricia; Cano, Amanda; Ettcheto, Miren; Camins, Antoni; García, Maria Luisa; Souto, Eliana B.This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles wil...
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana B.; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Biofate and cellular interactions of lipid nanoparticles
Baldim, Iara; Oliveira, Wanderley P.; Rao, Rekha; Raghuvir, Singh; Mahant, Sheefali; Gama, F. M.; Souto, Eliana B.By definition, drug targeting and delivery is the process of delivering a drug molecule to a specific site where the pharmacological effect is desired. A targeted release may simplify the drug administration protocols and reduce the amount of drug necessary, thus improving the cost-effectiveness and reducing the side effects. A drug administered by intravenous injection distributes in the whole body, reaching o...
Analysis of in vivo absorption of didanosine tablets in male adult dogs by HPLC
Severino, Patrícia; Silva, Heloisa [UNESP]; Souto, Eliana B.; Santana, Maria Helena A.; Dalla Costa, Teresa Cristina T.Made available in DSpace on 2022-04-28T19:00:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-01-01; Didanosine is an effective antiviral drug in untreated and antiretroviral therapy-experienced patients with Human Immunodeficiency Virus (HIV). An automated system using on-line solid extraction and High Performance Liquid Chromatography (HPLC) with ultraviolet (UV) detection was developed and validated...