2 documents found, page 1 of 1
Genotoxicity Assessment of Metal-Based Nanocomposites Applied in Drug Delivery
Cardoso, Sara; da Silva, Classius F; Severino, Patrícia; Silva, Amélia M.; Souto, Selma B; Zielińska, Aleksandra; Karczewski, Jacek; Souto, Eliana B.Nanocomposites as drug delivery systems (e.g., metal nanoparticles) are being exploited for several applications in the biomedical field, from therapeutics to diagnostics. Green nanocomposites stand for nanoparticles of biocompatible, biodegradable and non-toxic profiles. When using metal nanoparticles for drug delivery, the question of how hazardous these "virus-sized particles" can be is posed, due to their n...
(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant A...
Souto, Eliana B.; Zielińska, Aleksandra; Souto, Selma B; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Atanasov, Atanas G.In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized with Poloxamer® 188 in aqueous dispersion to modify the release profile of the loaded monoterpene derivative. We also evaluated the role of SLNs in lipid peroxidation and cytotoxicity in a spontaneously transformed aneuploid immortal keratinocyte cell line from a...