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Evaluation of the fibulin 5 gene polymorphism as a factor related to the occurr...
Paula,Marcus Vinicius Barbosa de; Lira Júnior,Marcos Antônio de Farias; Monteiro,Vivian Costa e Silva Crocco; Souto,Ricardo PeresSUMMARY OBJECTIVE Pelvic organ prolapse (POP) is a very frequent situation in our population that may lead to a significant decrease in patients’ quality of life. Currently, we are looking for predictive factors for the development of POPs; thus, this study seeks to evaluate whether the Fibulin 5 polymorphism (FBLN5) is associated with the occurrence of POP. METHODS This is a cohort study with postmenopausal wo...
Association between col1a2 Polymorphism and the Occurrence of Pelvic Organ Prol...
Rosa,Josyandra Paula de Freitas; Haddad,Raphael Federicci; Maeda,Fabiana Garcia Reis; Souto,Ricardo Peres; Fernandes,Cesar Eduardo; Oliveira,Emerson deAbstract Objective To evaluate the rs42524 polymorphism of the procollagen type I alpha (α) 2 (COL1A2) gene as a factor related to the development of pelvic organ prolapse (POP) in Brazilian women. Methods The present study involved 112 women with POP stages III and IV (case group) and 180 women with POP stages zero and I (control group). Other clinical data were obtained by interviewing the patients about thei...
Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors...
Ghersel,Frederico Rezende; Souto,Ricardo Peres; Gonzales,Ester Wilma Pacheco; Paulo,Denise Souza; Fernandes,César Eduardo; Oliveira,EmersonAbstract Objective To evaluate the C-1562T matrix metalloproteinase 9 (MMP9) gene polymorphisms as risk factors related to the occurrence of pelvic organ prolapse (POP) and to identifytheclinicalvariablesassociatedwith theoccurrenceof thedisease.Epidemiological studies of risk factors for POP do not explain why nulliparous women with no known risk factors also develop POP. Therefore, genetic factors may be invo...