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Association between Matrix Metallopeptidase 9 Polymorphism and Breast Cancer Risk

Felizi,Rogério Tadeu; Veiga,Melissa Gonzalez; Carelli Filho,Ivo; Souto,Ricardo Peres do; Fernandes,César Eduardo; Oliveira,Emerson

Abstract Objective Epidemiological studies have shown evidence of the effect of genetic variations in the pathogenesis of breast cancer and have suggested a relationship of the disease with genetic polymorphisms. Matrix metallopeptidase 9 (MMP-9) is a collagenase responsible for the degradation of type IV collagen, the major component of the basement membrane, and other essential extra cellular matrix component...

Date: 2018   |   Origin: Oasisbr

The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breas...

Veiga,Melissa Gonzalez; Felizi,Rogério Tadeu; Reis,Dayane Guerino; Carelli Filho,Ivo; Fernandes,Cesar Eduardo; Souto,Ricardo Peres do; Oliveira,Emerson

Abstract Objective Epidemiological studies have shown evidence of the effect of sex hormones in the pathogenesis of breast cancer, and have suggested a relationship of the disease with variations in genes involved in estrogen synthesis and/or metabolism. The aim of the present study was to evaluate the association between the CYP3A4*1B gene polymorphism (rs2740574) and the risk of developing breast cancer. Meth...

Date: 2018   |   Origin: Oasisbr

Expressão gênica de adiponectina no tecido adiposo epicárdico após intervenção ...

Spener,Roberta França; Breda,João Roberto; Pires,Adilson Casemiro; Pinhal,Maria Aparecida da Silva; Souto,Ricardo Peres do

INTRODUÇÃO: A visão clássica de tecido adiposo como um reservatório passivo para o armazenamento de energia não é mais válido. Na última década, o tecido adiposo tem demonstrado funções endócrinas, sendo o peptídeo mais abundante secretado pelos adipócitos a adiponectina. O tecido adiposo epicárdico (TAE) é distribuído em torno das artérias coronárias e, a lesão endovascular causada pela presença de stent metál...

Date: 2011   |   Origin: Oasisbr

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