3 documents found, page 1 of 1
Peptides ToAP3 and ToAP4 decrease release of inflammatory cytokines through TLR...
Veloso Júnior, Paulo Henrique de Holanda; Simon, Karina Smidt; Castro, Raffael Júnio Araújo de; Coelho, Luísa Coutinho; Hurtado Erazo, Fabián AndresAntimicrobial peptides (AMPs) are small molecules with microbicidal and immunoregulatory activities. In this study we evaluated the anti-inflammatory and antimicrobial activities of peptides ToAP3 and ToAP4, AMPs from the venom of the Brazilian scorpion Tityus obscurus. To test the peptides’ activity, murine bone marrow-derived macrophages (BMDMs) or dendritic cells (BMDCs) were stimulated with peptides plus LP...
Fraternine, a novel wasp peptide, protects against motor impairments in 6-OHDA ...
Biolch, Andréia Mayer; Oliveira, Danilo Gustavo Rodrigues de; Amaral, Henrique de Oliveira; Campos, Gabriel Avohay Alves; Gonçalves, Jacqueline CoimbraParkinson’s disease (PD) is a progressive neurodegenerative condition that affects the Central Nervous System (CNS). Insect venoms show high molecular variability and selectivity in the CNS of mammals and present potential for the development of new drugs for the treatment of PD. In this study, we isolated and identified a component of the venom of the social wasp Parachartergus fraternus and evaluated its neur...
Estudos visando à sintese de compostos com potencial atividade biológica, conte...
Souza, Adolfo Carlos Barros deDissertação (mestrado)—Univerdidade de Brasília, Instituto de Química, 2010.; O centro quinônico foi utilizado para a preparação de aminonaftoquinonas alifáticas na tentativa de aplicar essa classe de moléculas na reação multicomponente do tipo Hantszch. Após a caracterização por RMN de 1H e 13C dos compostos sintetizados, a partir da adição nucleofílica das aminas na bromonaftoquinona, observou-se que houve a ...