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Exogenous surfactant prevents hyperoxiainduced lung injury in adult mice.
Bezerra, Frank Silva; Ramos, Camila de Oliveira; Castro, Thalles de Freitas; Araújo, Natália Pereira da Silva; Souza, Ana Beatriz Farias deBackground: In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to reverse hypoxemia. Alterations of endogenous surfactant system participate in the pulmonary dysfunction observed in ARDS. Administration of exogenous surfactant could have protective effects durin...
Environmental enrichment promotes antioxidant effect in the ventrolateral medul...
Sousa, Luiz Eduardo de; Favero, Iuri Ferrari Del; Bezerra, Frank Silva; Souza, Ana Beatriz Farias de; Alzamora, Andréia CarvalhoBackground: Arterial hypertension is a precursor to the development of heart and renal failure, furthermore is associated with elevated oxidative markers. Environmental enrichment of rodents increases performance in memory tasks, also appears to exert an antioxidant effect in the hippocampus of normotensive rats. Objectives: Evaluate the effect of environmental enrichment on oxidative stress in the ventrolatera...
Efeitos da dieta hiperlipídica sobre o desequilíbrio redox e a resposta inflama...
Souza, Ana Beatriz Farias dePrograma de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa de Pós Graduação, Universidade Federal de Ouro Preto.; A obesidade é uma doença de etiologia complexa e multifatorial influenciada por fatores genéticos, sociais e ambientais. O aumento da adiposidade leva a um quadro inflamatório crônico e provoca alterações em diversos sistemas como o sistema...
High-Fat diet increases HMGB1 expression and promotes lung inflammation in mice...
Souza, Ana Beatriz Farias de; Chírico, Máira Tereza Talma; Cartelle, Christiane Teixeira; Costa, Guilherme de Paula; Silva, André Talvani Pedrosa daThis study aims to evaluate the effects of a high-fat diet and mechanical ventilation on the pulmonary and systemic inflammatory response in C57BL/6 mice. Male C57BL/6 mice were divided into two groups: one received a standard diet, and the other received a high-fat diet. After 10 weeks, the groups were further divided into two groups each: control group (CG), mechanical ventilation group (MVG), diet group (DG)...
Tobacco-free cigarette smoke exposure induces anxiety and panic-related behavio...
Chírico, Máira Tereza Talma; Bezerra, Frank Silva; Guedes, Mariana Reis; Souza, Ana Beatriz Farias de; Silva, Fernanda Cacilda dos SantosSmokers, who generally present with lung damage, are more anxious than non-smokers and have an associated augmented risk of panic. Considering that lung damage signals specific neural pathways that are related to affective responses, the aim of the present study was to evaluate the influence of pulmonary injury on anxiety and panic-like behaviours in animals exposed to cigarette smoke with and without tobacco. ...