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Resistance of Leishmania (Viannia) braziliensis to nitric oxide: correlation wi...

Souza, Anselmo; Giudice, Ângela; Pereira, Júlia M. B.; Guimarães, Luiz Henrique Santos; Jesus, Amélia Maria Ribeiro de; Moura, Tatiana Rodrigues de

BACKGROUND: Nitric oxide (NO) produced in macrophages plays a pivotal role as a leishmanicidal agent. A previous study has demonstrated that 20% of the L. (V.) braziliensis isolated from initial cutaneous lesions of patients from the endemic area of Corte de Pedra, Bahia, Brazil, were NO resistant. Additionally, 5 to 11% of the patients did not respond to three or more antimony treatments" (refractory patients)...

Date: 2014   |   Origin: Oasisbr
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