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BR-BCSC Signature: The Cancer Stem Cell Profile Enriched in Brain Metastases th...

Dionísio, MR; Vieira, AF; Carvalho, R; Conde, I; Oliveira, M; Gomes, M; Pinto, MT; Pereira, P; Pimentel, J; Souza, C; Marques, MMC; Silva, VD

Brain metastases remain an unmet clinical need in breast oncology, being frequently found in HER2-overexpressing and triple-negative carcinomas. These tumors were reported to be highly cancer stem-like cell-enriched, suggesting that brain metastases probably arise by the seeding of cancer cells with stem features. Accordingly, we found that brain-tropic breast cancer cells show increased stem cell activity and ...


Effects of mowing regime on diversity of Mediterranean roadside vegetation – im...

Simões, MP; Belo, A.D.F.; Souza, C

Shrub development on road outside verges can provide alternative wildlife habitat. However, management of inside verges should keep vegetation at a height consistent with proper road visibility and safety. The influence of management on vegetation was analyzed on the inside verge of two Portuguese roads, one mown once and another twice a year. Specifically, the effect of mowing frequency on shrub abundance and ...


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