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Effectiveness of an immunohistochemical protocol for Leishmania detection in di...
Marques, Fernanda A; Soares, Rodrigo P; Almeida, Greg?rio G; Souza, Carolina Carvalho de; Melo, Maria Norma; Pinto, Sebasti?o AlvesUniversidade Federal de Minas Gerais. Instituto de Ci?ncias Biol?gicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brazil.; Funda??o Oswaldo Cruz. Centro de Pesquisas Ren? Rachou. Belo Horizonte, MG, Brazil.; Universidade Federal de Minas Gerais. Instituto de Ci?ncias Biol?gicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brazil.; Universidade Federal de Minas Gerais. Instituto de Ci?ncias B...
A potential link among antioxidant enzymes, histopathology, and trace elements ...
Souza, Carolina Carvalho de; Barreto, Tatiane Oliveira; Silva, Sydnei Magno da; Pinto, Aldair Junio Woyames; Figueiredo, Maria MartaCanine visceral leishmaniasis (CVL) is a severe and fatal systemic chronic inflammatory disease. We investigated the alterations in, and potential associations among, antioxidant enzymes, trace elements and histopathology in CVL. Blood and tissue levels of Cu-Zn superoxide dismutase, catalase and glutathione peroxidase were measured in mixed-breed dogs naturally infected with Leishmania infantum chagasi, sympto...
Histopathology of Leishmania major infection : revisiting L. major histopatholo...
Cangussú, Silvia Dantas; Souza, Carolina Carvalho de; Campos, Camila França; Vieira, Leda Quercia; Afonso, Luís Carlos CroccoWe describe the relationship between lesion outcome and histopathological hallmarks in susceptible (BALB/c) and resistant (C57BL/6 and IL-4-deficient BALB/c) mouse strains over the course of a 12-week-infection with Leishmania major in the ear. The infiltration of mononuclear cells and polymorphonuclear cells occurred within 6 h and mononuclear cells predominated one week post-infection. Permissive intracellula...
Short-term protection conferred by Leishvacin® against experimental Leishmania ...
Carneiro, Matheus Batista Heitor; Sousa, Louisa Maria de Andrade e; Vaz, Leonardo Gomes; Santos, Liliane Martins dos; Vilela, LucianoTo date, there is no vaccine available against human leishmaniasis. Although some vaccination protocols can induce immunity in murine models, they fail to induce protection in humans. The reasons for that remain unclear. The aimof the present study was to characterize the changes in the pattern of the immune response during subcutaneous vaccination with Leishvacin® in mice. We also investigated whether IFN-γ an...
The endogenous cytokine profile and nerve fibre density in mouse ear Leishmania...
Cangussú, Silvia Dantas; Souza, Carolina Carvalho de; Castro, Maria Salete de Abreu; Vieira, Leda Quercia; Cunha, Fernando de QueirozSeveral reports have shown that cutaneous leishmaniasis lesions are painless, suggesting that Leishmania infection interferes with pain perception. Comparisons of inflammation-induced hyperalgesia between BALB/c and C57BL/6 mice have been little explored in the literature, and comparative data regarding nociception in leishmaniasis are non-existent. In susceptible BALB/c mice and resistant C57BL/6 mice that wer...
American tegumentary leishmaniasis : effectiveness of an immunohistochemical pr...
Alves, Cibele Fontes; Alves, Cíntia Fontes; Figueiredo, Maria Marta; Souza, Carolina Carvalho de; Coelho, George Luiz Lins Machado; Melo, Maria NormaBackground: American tegumentary leishmaniasis (ATL) is endemic in Latin America, where Brazil has over 27 thousand cases per year. The aim of the present study was to develop an immunohistochemical method (IHC) for ATL diagnosis. For this purpose, we used serum from a dog naturally infected with Leishmania (L) infantum (canine hyperimmune serum) as the primary antibody, followed by a detection system with a se...