3 documents found, page 1 of 1
Development of a canine epidermis equivalent model for evaluation of sensitization
Marques, M; Nunes, J; Ustymenko, B; Lagoa, Tânia; Fialho, Luísa; Martins, Luís; Burke, Anthony; Souza, E; Filho, César; Craveiro, Alexandre; Costa, AnaBackground Canine atopic dermatitis (cAD) is a genetic-predisposed allergic and pruritic inflammatory skin condition, associated with sensitization to environmental allergens. Keratinocytes can produce several inflammatory mediators, in response to several other host mediators, antigens, and pathogens by virtue of their wide range of surface receptors, some of them dysregulated in cAD individuals. A histotypica...
Development of a canine skin analog
Marques, M; Nunes, J; Fialho, Luisa; Martins, Luís; Burke, Anthony; Souza, E; Craveiro, Alexandre; Costa, Ana; Branco, Sandra; Antunes, CéliaBackground. Skin covers an extensive area of the body and comprises three major layers, subcutis, dermis, and epidermis. This organ is one of the most tested for toxicity and safety evaluation during the process of drug research and development, in past usually performed in vivo using animals. On the last years a concern of sustainable and eco-friendly approach has been developing, with the expansion of non-ani...
Biocompatibility and biosafety analysis of chitosan hydrogels using organotypic...
Nunes, J; Marques, M; Sterghite, D; Branco, S; Martins, Luís; Silva, M; Campos-Gonçalves, I; Souza, E; Filho, César; Craveiro, AlexandreBackground: Frequent dog consultations are due to skin wounds (Holland, 2019), with different trauma causes, like bites, burns and others. The majority of these wounds are not fatal, but cause long-lasting discomfort, demanding frequent medical care which may affect owners financially (Fahie & Shettko, 2007). Despite several pharmaceuticals available for dog wound treatment, new antibiotic-free efficient option...