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Differential expression of MYC in H. pylori-related intestinal
Fernandes, Isabelle Joyce de Lima Silva; Alves, Markênia Kélia Santos; Lima, Valeska Portela; Lima, Marcos Antônio Pereira deEvidence suggests that the carcinogenic process guided by Helicobacter pylori is related to the expression of cell cycle and apoptosis proteins as BCL-2, BAX, and MYC. However, the literature is conflicting regarding the expression frequency in the histological subtypes and did not consider cagA gene presence. To investigate the expression of these proteins considering the histological subtypes of gastric cance...
Prevalence of Helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in ga...
Lima, Valeska Portela; Silva-Fernandes, Isabelle Joyce de Lima; Alves, Markênia Kélia Santos; Rabenhorst, Silvia Helena BaremPurpose: To investigate the frequency and the association of vac A alleles, cag A, cag E and vir B11 genes of Helicobacter pylori from patients with gastric cancer, considering the clinic histopathological parameters. Methods : One hundred and one gastric adenocarcinoma tissues were assessed by PCR to detect H. pylori and vac A alleles, cag A, cag E and vir B11. Results : The distribution of cases according to ...
The relationship between Helicobacter pylori genes cag E and vir B11 and gastri...
Lima, Valeska Portela; Lima, Marcos Antonio Pereira de; Ferreira, Márcia Valéria Pitombeira; Barros, Marcos Aurélio Pessoaackground: The association between Helicobacter pylori gene diversity and gastric cancer has been poorly reported, although it is one of the important ways to explain the gastric pathogenesis. The aim of this study was to investigate the frequency of cag E and vir B11 genes in H. pylori isolated from patients with gastric cancer and to analyze the histology profiles. Materials and methods: The presence of H. py...
p27 KIP1 expression in gastric cancer : differential pathways in the histologic...
Alves, Markênia Kélia Santos; Lima, Valeska Portela; André, Ângela Rosa; Ferreira, Márcia Valéria Pitombeira; Barros, Marcos Aurélio PessoaObjective. Decreases in p27 KIP1 and C-MYC expression have been associated with Helicobacter pylori infection. Furthermore, C-MYC seems to be a transcriptional repressor of p27 KIP1 . Therefore, in a series of gastric adenocarcinomas we studied the association of p27 KIP1 expression with H. pylori genotype ( vac A, cag A, cag E and vir B11) and the involvement of C-MYC in this process. Material and methods. Exp...
MTHFR C677T polymorphism and differential methylation status in gastric cancer ...
Neves Filho, Eduardo Henrique Cunha; Alves, Markênia Kélia Santos; Lima, Valeska Portela; Rabenhorst, Silvia Helena BaremAbstract MTHFR C677T and Helicobacter pylori infec- tion are believed to play critical roles in the DNA methylation process, an epigenetic feature frequently found in gastric cancer. The aim of this study was to verify the associations between the MTHFR C677T polymorphism and the methylation status of three gastric cancer-related genes. The influence of H. pylori strains was also assessed. DNA extracted from 71...
Genes associados à virulência de Helicobacter pylori
Lima, Valeska Portela; Rabenhorst, Silvia Helena BaremO câncer gástrico é uma doença multifatorial, na qual a interação das características genéticas do indivíduo com o ambiente é de suma importância. Entre os fatores envolvidos na carcinogênese gástrica, destaca-se a infecção por Helicobacter pylori. Entretanto, nem todos os indivíduos portadores da infecção por essa bactéria desenvolvem câncer gástrico, já que essa doença está relacionada tanto a fatores do hosp...
Helicobacter pylori (CagA) and Epstein Barr virus infection in gastric carcinom...
Lima, Valeska Portela; Lima, Marcos Antonio Pereira de; André, Ângela Rosa; Ferreira, Márcia Valéria Pitombeira; Barros, Marcos Aurélio PessoaAIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistr...
Impacto dos genes cag-pai (caga, cage e virb11) e vaca do helicobacter pylori n...
Lima, Valeska PortelaThe gastric cancer is the fourth more frequent cancer, and the second cause of death for cancer in the world, recording approximately 934 thousand of new cases and 700 thousand of deaths a year. In Brazil, the gastric cancer is the sixth more frequent malignant tumor. In the Northeast area, it is the second more frequent cancer among the men and fourth among the women. In the state of Ceara, it is the third mor...