5 documents found, page 1 of 1
Relação do dano oxidativo, mutação do gene HFE e fator de necrose tumoral (TNF-...
Souza, Geane Felix deIntroduction: Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and dysplasia in one or more cell lines, peripheral cytopenias and a variable risk of progression to acute leukemia. Anemia is present in 80 % of patients. Many develop transfusion dependence and iron overload (IOL), which leads to generation of reactive oxygen species (ROS). Oxidative stress, together with tumor necros...
HFE gene mutation and oxidative damage biomarkers in patients with myelodysplas...
Souza, Geane Felix de; Ribeiro Jr, Howard Lopes; Sousa, Juliana Cordeiro de; Heredia, Fabíola Fernandes; Freitas, Rivelilson Mendes deObjective: A relation between transfusional IOL (iron overload), HFE status and oxidative damage was evaluated. Design, setting and participants: An observational cross-sectional study involving 87 healthy individuals and 78 patients with myelodysplastic syndromes (MDS) with and without IOL, seen at University Hospital of the Federal University of Ceará, Brazil, between May 2010 and September 2011. Methods: IOL...
Increased parameters of oxidative stress and its relation to transfusion iron o...
Souza, Geane Felix de; Barbosa, Maritza Cavalcante; Santos, Talyta Ellen de Jesus; Carvalho, Teresa Maria de Jesus Ponte; Freitas, Rivelilson Mendes deMyelodysplastic syndromes (MDS) are group of stem cell disorders characterised by peripheral cytopaenias and a variable risk of progression to acute myeloid leukaemia. Most patients have anaemia and many develop transfusion dependence and iron overload (IOL), considered to be a negative independent prognostic factor associated with a higher risk of leukemic transformation and shorter survival.
Avaliação da toxicidade aguda do epóxilimoneno em camundongos adultos
Almeida, Antonia Amanda Cardoso de; Carvalho, Rusbene Bruno Fonseca de; Sousa, Damião Pergentino de; Souza, Geane Felix de; Oliveira, Johanssy da SilvaIntroduction: the biodiversity of global flora provides important molecules for the treatment and prevention of various human diseases, but most often their toxicities are not evaluated. Objective: evaluate the toxicity of monoterpenoid limonene epoxidein mice treated acutely with repeated doses (25, 50 and 75 mg/kg) orally on hematological and biochemical parameters. Methods: forty mice divided infour groups (...
Postoperative nursing conduct towards children experiencing cardiac surgery: st...
Monteiro, Flávia Paula Magalhães; Melo, Renata Pereira de; Souza, Geane Felix de; Araujo, Thelma Leite de; Lima, Franscisca Elisângela TeixeiraCongenital cardiopathies represent anomalies including structural and functional heart defects, which demand early nursing intervention at the bedside. The present study aimed at analyzing studies that addressed the nursing care provided to children postoperatively following cardiac surgery. It consists of an integrative review of the literature from different databases, using the descriptors: Nursing care; Car...