3 documents found, page 1 of 1
Preclinical evidences for an antimanic effect of carvedilol
Souza, Greicy Coelho de; Gomes, Julia Ariana de S.; Queiroz, Ana Isabelle de Góis; Araújo, Maíra Morais de; Cavalcante, Lígia MenezesOxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that CVD woul...
Estudo dos efeitos do carvedilol em um modelo animal de mania em ratos
Souza, Greicy Coelho deBipolar disorder (BD) is a psychiatric disorder with multifactorial development and neuroprogressive characterized by oscillation between periods of manic and depressive episodes. It is estimated that the disease affects about 1 - 2% of the worldwide population and it takes about 10 years to a definitive diagnosis and appropriate treatment. BD brings many impairment of quality of life of patients, generating hi...
Prevention and reversal of ketamine-induced schizophrenia related behavior by m...
Monte, Aline Santos; Souza, Greicy Coelho de; McIntyre, Roger S.; Soczynska, Joanna K.; Santos, Júnia Vieira dos; Cordeiro, Rafaela CarneiroIt has been hypothesized that oxidative imbalance and alterations in nitrergic signaling play a role in the neurobiology of schizophrenia. Preliminary evidence suggests that adjunctive minocycline treatment is efficacious for cognitive and negative symptoms of schizophrenia. This study investigated the effects of minocycline in the prevention and reversal of ketamine-induced schizophrenia-like behaviors in mice...