2 documents found, page 1 of 1
Stability of clavulanic acid in PEG/citrate and liquid–liquid extraction in aqu...
Carneiro-da-Cunha, M. N.; Souza, K. P. S.; Mota, A.; Teixeira, J. A.; Porto, C. S.; Porto, Tatiana Souza; Porto, Ana L. F.β-Lactamases are enzymes responsible for the hydrolysis of β-lactam antibiotics, being produced by several pathogenic bacteria. Clavulanic acid is a commercially and clinically important β-lactamase inhibitor, its extraction being possible by the application of aqueous two-phase system. In this study, clavulanic acid stability was investigated at different molar mass PEG (400, 1 000 and 20 000 g mol−1) and at d...
Evaluation the best condition of Fibrinolytic protease production using factori...
Silva, J. M.; Clementino, E. L.; Souza, K. P. S.; Sales, Amanda Emmanuelle; Nascimento, Thiago Pajeú; Teixeira, J. A.; Porto, Tatiana SouzaFibrinolytic enzymes have the ability to degrade fibrin clots formed for avoiding intravascular thrombosis. In the pharmaceutical industry there is a search for new fibrinolytic agent that reduces the production cost and increasing productivity. The use of microorganism for enzyme production, such as the genus Streptomyces has been reported. Streptomyces is a Gram-positive bacteria, responsible for producing ma...