7 documents found, page 1 of 1
Validation of a capillary zone electrophoresis method for the determination of ...
Faria, Adriana Foncesa; Souza, Marcus V. N. de; Oliveira, Marcone Augusto Leal deUm método alternativo por eletroforese capilar de zona (CZE) para determinação de ciprofloxacina (CPFLX), gatifloxacina (GTFLX), moxifloxacina (MFLX) e ofloxacina (OFLX) foi validado. O sistema de eletrólito utilizado consistiu da mistura de 25 mmol L-1 de TRIS/ HCl e 15 mmol L-1 de tetraborato de sódio em meio aquoso resultando em pH 8,87. A análise foi realizada sob detecção direta por UV em 282 nm com tempo ...
Different classical hydrogen-bonding patterns in three salicylaldoxime derivati...
Gomes, Ligia Rebelo; Souza, Marcus V. N. de; Da Costa, Cristiane F.; Wardell, James L.; Low, John NicolsonThe crystal structures of three salicyaldoxime compounds, namely 2-hy-droxy-4-methyl-benzaldehyde oxime, C8H9NO2, 1, 2,4-di-hydroxy-benzaldehyde oxime, C7H7NO3, 2, and 2-hy-droxy-4-meth-oxy-benzaldehyde oxime, C8H9NO3, 3, are discussed. In each compound, the hydroxyl groups are essentially coplanar with their attached phenyl group. The inter-planar angles between the C=N-O moieties of the oxime unit and their a...
Crystal structures and Hirshfeld surfaces of four methoxybenzaldehyde oxime der...
Gomes, Ligia R.; Souza, Marcus V. N. de; Da Costa, Cristiane F.; Wardell, James L.; Low, John NicolsonThe crystal structures of four (E)-meth-oxy-benzaldehyde oxime derivatives, namely (2-meth-oxy-benzaldehyde oxime, 1, 2,3-di-meth-oxy-benzaldehyde oxime, 2, 4-di-meth-oxy-benzaldehyde oxime, 3, and 2,5-di-meth-oxy-benzaldehyde oxime, 4, are discussed. The arrangements of the 2-meth-oxy group and the H atom of the oxime unit are s-cis in compounds 1-3, but in both independent mol-ecules of compound 4, the arrang...
Three new platinum complexes containing fluoroquinolones and DMSO: Cytotoxicity...
Oliveira, Leticia P. de; Carneiro, Zumira A.; Ribeiro, Camila M. [UNESP]; Lima, Mauricio F.; Paixao, Drielly A.; Pivatto, Marcos; Souza, Marcus V. N. deMade available in DSpace on 2018-11-29T14:59:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); This work describes the synthesis, ...
Biological evaluation of isoniazid derivatives as an anticancer class
Rodrigues, Felipe A. R.; Oliveira, Augusto C. A.; Cavalcante, Bruno C.; Pessoa, Claudia; Pinheiro, Alessandra C.; Souza, Marcus V. N. deA series of thirty-two isoniazid derivatives have been evaluated for their activity against four human cancer cell lines with potent cytotoxicity (IC50 ranging from 0.61 to 3.36 μg/mL). The structure-activity relationship (SAR) analysis indicated the number, the positions, and the types of substituents attached to the aromatic ring as being critical factors for the biological activity. Briefly, we observed that...
Cytotoxic evaluation of substituted benzaldehydes
Rodrigues, Felipe A. R.; Oliveira, Augusto C. A.; Cavalcanti, Bruno C.; Costa, Marcília P.; Pessoa, Claudia; Souza, Marcus V. N. deA series of fifty-four commercial aldehydes have been synthesized and evaluated for their activity against peripheral blood mononuclear cells (PBMC) and four human cancer cell lines, exhibiting potent citotoxicity (IC50 ranging from 0.36 to 4.75 μg mL-1). The structureactivity relationship (SAR) analysis indicated that the number, the positions and the type of substituents attached into the aromatic and heteroa...
Mefloquine–Oxazolidine derivatives : a new class of anticancer agents
Rodrigues, Felipe A. R.; Bomfim, Igor da S.; Cavalcanti, Bruno C.; Pessoa, Claudia; Goncalves, Raoni S. B.; Wardell, James L.; Wardel, Solange M. S. V.A series of 23 racemic mefloquine–oxazolidine derivatives, 4-[3-(aryl)hexahydro[1,3]oxazolo[3,4-a]pyridin- 1-yl]-2,8-bis(trifluoromethyl)quinolines, derived from (R*, S*)-(±)-mefloquine and arenealdehydes, have been evaluated for their activity against four cancer cell lines (HCT-8, OVCAR-8, HL-60, and SF-295). Good cytotoxicities have been determined with IC50 values ranging from 0.59 to 4.79 lg/mL. In general...