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Design and synthesis of new Benzophenone derivatives with in vivo anti-inflamma...
Santos, Marcelo H. dos; Januario, Jaqueline P.; Souza, Thiago B. de; Lavorato, Stefânia N.; Maiolini, Tatiane C. S.; Domingos, Olívia S.A series of novel benzophenone derivatives containing a thiazole heterocyclic nucleus were designed by molecular hybridization. Molecular docking studies have demonstrated the inhibitory potential of the designed compounds against cyclooxygenase (COX) isoenzymes. These compounds were synthesized, characterized, and evaluated for their anti-inflammatory properties by the croton oil-induced ear edema assay to exa...
Date: 2019
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Origin: Oasisbr