Encontrados 4 documentos, a visualizar página 1 de 1
Validation of a UV-spectrophotometric analytical method for determination of LP...
Ferraz, Rafaela Siqueira; Mendonça, Elisângela Afonso Moura; Silva, Jéssica Priscila Avelino; Cavalcanti, Isabella Macário FerroThe aim of this study was to develop and validate a UV spectrophotometric method for determination of LPSF/AC04 from inclusion complex and encapsulated into liposomes. The validation parameters were determined according to the International Conference on Harmonisation (ICH) and National Health Surveillance Agency (ANVISA) guidelines. LPSF/AC04 was determined at 250 nm in methanol by a UV spectrophotometric meth...
On the application of knoevenagel condensation for the synthesis of benzylidene...
Souza, Ana Maria Alves de; Guarda, Vera Lúcia de Miranda; Leite, Lucia Fernanda Cavalcanti da Costa; Barbosa Filho, José MariaThe synthesis and physico-chemical properties of new 6-acetylamino or 6-benzoyl-amino 2-benzylidene-4-methyl-4Hbenzo[1,4]thiazin-3-ones and 6-benzoylamino or 6-nitro 2-benzylidene-4H-benzo[1,4]thiazin-3-ones are described. These benzylidene benzothiazine compounds were prepared by the Knoevenagel condensation with benzaldehydes. The configurations and conformations of benzylidene benzothiazine derivatives were ...
GQ-16, a novel peroxisome proliferator-activated receptor (PPAR ) ligand, promo...
Amato, Angélica Amorim; Rajagopalan, Senapathy; Lin, Jean Z.; Carvalho, Bruno de Melo; Figueira, Ana Carolina Migliorini; Lu, Jenny; Ayers, Stephen D.ABSTRACT; Background: PPAR agonists improve insulin sensitivity but also evoke weight gain. Results: GQ-16 is a PPAR partial agonist that blocks receptor phosphorylation by Cdk5 and improves insulin sensitivity in diabetic mice in the absence of weight gain. Conclusion: The unique binding mode of GQ-16 appears to be responsible for the compound’s advantageous pharmacological profile. Significance: Similar compo...
Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythemat...
Silva, Juliana Cruz da; Mariz, Henrique Ataide; Rocha Júnior, Laurindo Ferreira da; Oliveira, Priscilla Stela Santana de; Dantas, Andrea TavaresOBJECTIVES: Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. The purpose of this study was to evaluate the immunomodulatory activity of hydroxychloroquine in T helper 17 (Th17) cytokines in hea...