3 documents found, page 1 of 1
The Presence and Extension of Myocardial Fibrosis in the Undetermined Form of C...
Noya-Rabelo,Marcia Maria; Macedo,Carolina The; Larocca,Ticiana; Machado,Admilson; Pacheco,Thais; Torreão,Jorge; Souza,Bruno Solano de FreitasAbstract Background: Previous data has shown that patients in the indeterminate form of Chagas disease may present myocardial fibrosis as shown on through magnetic resonance imaging (MRI). However, there is little information available regarding the degree of severity of myocardial fibrosis in these individuals. This variable has the potential to predict the evolution of Chagas’ disease into its cardiac form. O...
Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease
Cruz,Gabriela da Silva; Angelo,Ana Luiza Dias; Larocca,Ticiana Ferreira; Macedo,Carolina Thé; Noya-Rabelo,Márcia; Correia,Luís Claudio LemosAbstractBackground:Galectin-3, a β-galactoside binding lectin, has been described as a mediator of cardiac fibrosis in experimental studies and as a risk factor associated with cardiovascular events in subjects with heart failure. Previous studies have evaluated the genetic susceptibility to Chagas disease in humans, including the polymorphisms of cytokine genes, demonstrating correlations between the genetic p...
Transplante de células mesenquimais de tecido adiposo na cardiopatia chagásica ...
Larocca,Ticiana Ferreira; Souza,Bruno Solano de Freitas; Silva,Cristina Aragão; Kaneto,Carla Martins; Alcantara,Adriano Costa de; Azevedo,Carine MachadoFUNDAMENTO: A doença de Chagas, causada pelo protozoário Trypanosoma cruzi, é uma das mais importantes causas de insuficiência cardíaca na América Latina. A terapia celular vem sendo investigada como uma possível opção terapêutica para pacientes com doenças cardiovasculares. OBJETIVO: O objetivo deste estudo foi avaliar os efeitos da terapia com células-tronco mesenquimais em um modelo experimental de cardiomio...