3 documents found, page 1 of 1
Unravelling longitudinal mitochondrial DNA mutations in Multiple Sclerosis : As...
Cortes-Figueiredo, FilipeMultiple Sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease with a multifactorial undetermined etiology that causes demyelination and neuroaxonal loss in the central nervous system (CNS), leading to disability, particularly in women. Mitochondria are pivotal for MS disease activity and progression: (I) in the CNS, mitochondrial dysfunction is the main trigger for neuroaxonal loss and br...
Retinoids are not linked to risk of multiple sclerosis: a Danish nationwide coh...
Cortes-Figueiredo, Filipe; Nielsen, Nete Munk; Stenager, Egon; Paul, Friedemann; Hallas, Jesper; Kristensen, Kasper BruunBackground and purpose: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system with an undetermined etiology. Retinoids may have immunomodulatory effects that favorably influence MS progression. We aimed to explore the yet unknown relationship between exposure to retinoids and the risk of acquiring MS. Methods: We performed a nationwide cohort study in the Danish population i...
Atherosclerosis and bone loss in humans: results from deceased donors and from ...
Carmona-Fernandes, Diana; Barreira, Sofia; Leonardo, Natacha; Casimiro, Renata I.; Castro, Alice M.; Santos, Pedro Oliveira; Fernandes, António N.Background and Aims: Atherosclerosis and osteoporosis share common risk factors, as well as inflammatory mechanisms. Our aim was to understand how atherosclerotic lesions are related with disturbances in bone. Methods: Gene expression of pro-inflammatory and bone metabolism related proteins (IL-1β, IL-6, IL-17A, TNF, RANKL, OPG, COL1, CTSK, OCL, TRAP, CBFA1, DKK1, SOST, ADIPOQ, and ADIPOR1) were analyzed in art...