60 documents found, page 1 of 6

Prescription Patterns in Adult ADHD: The Reality at CHUC

Introduction: Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders, affecting around 2%‑4% of the adult population. The first‑line therapeutic intervention is psychostimulants such as methylphenidate and amphetamines. Second‑line therapy is used when stimulants are ineffective, intolerant, or contraindicated. Methods: Retrospective observational study of patients ...

Attention Deficit/Hyperactivity Disorder in Adults: Position of Portuguese Expe...

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often persists into adulthood, affecting approximately 1.5% - 3% of the adult population in Portugal. Untreated ADHD in adults is associated with increased risks of substance abuse, criminality, poor academic and professional performance. Less than 20% of adults with ADHD are properly diagnosed and treated due to overlapping s...

Perturbação de hiperatividade/défice de atenção no adulto: um posicionamento de...

A perturbação de hiperatividade e défice de atenção (PHDA) é uma perturbação do neurodesenvolvimento que frequentemente persiste na vida adulta, afetando aproximadamente 1,5% - 3% da população adulta em Portugal. A PHDA não tratada em adultos está ligada a um risco aumentado de abuso de substâncias, criminalidade, baixo desempenho académico e profissional. Menos de 20% dos adultos com PHDA são diagnosticados e ...

Frotteurism and Kleptomania in High-Functioning Autism Spectrum Disorder: A Cas...

Innate vulnerabilities in autism spectrum disorder (ASD) could increase the risk of comorbid psychiatric conditions and judicial problems. Persistent deficits in social communication, narrow, repetitive interests, or sensory impairments could lead to deviant behaviors. This case study refers to a 22-year-old male who exhibited behavioral particularities in agreement with the presence of frotteurism and kleptoma...

Síndrome de Wernicke-Korsakoff: uma Revisão Narrativa

Introdução: A Síndrome de Wernicke-Korsakoff engloba uma tríade clássica de confusão, ataxia e oftalmoplegia. Foi descrita pela primeira vez por Carl Wernicke. Sergei Korsakoff descreveu um quadro de amnésia associado ao alcoolismo crónico. Murawieff propôs uma etiologia comum para as duas síndromes. Contudo, a tríade completa é uma apresentação incomum, o que leva ao subdiagnóstico, particularmente em contexto...

Editorial: Neuroimaging in early intervention in psychiatry

Emotional interference and attentional control in schizophrenia-spectrum disord...

Background and objectives: Schizophrenia-spectrum disorders (SSD) are characterized by impaired emotion processing and attention. SSD patients are more sensitive to the presence of emotional distractors. But despite growing interest on the emotion-attention interplay, emotional interference in SSD is far from fully understood. Moreover, research to date has not established the link between emotional interferenc...

Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder

Background: This study aimed to compare brain asymmetry in patients with schizophrenia (SCZ), bipolar disorder (BPD), and healthy controls to test whether asymmetry patterns could discriminate and set boundaries between two partially overlapping severe mental disorders. Methods: We applied a fully automated voxel-based morphometry (VBM) approach to assess structural brain hemispheric asymmetry in magnetic reson...

Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Infl...

Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) is a crucial component of the cellular machinery responsible for Ca2+ homeostasis. The selective inhibition of SERCA by thapsigargin (TG) leads to perturbations in Ca2+ signaling, which can trigger endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) pathway is activated in response to ER stress and induces an adaptive response to preserve cell s...

Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to ...

Mass spectrometry (MS)-based techniques can be a powerful tool to identify neuropsychiatric disorder biomarkers, improving prediction and diagnosis ability. Here, we evaluate the efficacy of MS proteomics applied to human peripheral fluids of schizophrenia (SCZ) patients to identify disease biomarkers and relevant networks of biological pathways. Following PRISMA guidelines, a search was performed for studies t...