27 documents found, page 1 of 3
Assessing the In Vitro Inhibitory Effects on Key Enzymes Linked to Type-2 Diabe...
Spínola, Vítor; Castilho, Paula C.Methanolic leaf extracts of four Lauraceae species endemic to Laurisilva forest (Apollonias barbujana, Laurus novocanariensis, Ocotea foetens and Persea indica) were investigated for the first time for their potential to inhibit key enzymes linked to type-2 diabetes (α-amylase, α-glucosidase, aldose reductase) and obesity (pancreatic lipase), and protein glycation. Lauraceae extracts revealed significant inhibi...
Release of adsorbed ferulic acid in simulated gastrointestinal conditions
Martins, Gonçalo N.; Spínola, Vítor; Castilho, Paula C.Ferulic acid (FA) is a natural antioxidant with limited absorption when conjugated with biomolecules but whose free form is readily absorbed in the stomach and, to a lesser extent, in the ileum. The latter sufers from infammation and oxidative stress, so a novel strategy for the delivery of FA in this compartment of the gastrointestinal tract was developed. Using the neutral un-functionalized resin Lewatit® VP ...
Inhibition of α-amylase, α-glucosidase and pancreatic lipase by phenolic compou...
Spínola, Vítor; Llorent-Martínez, Eulogio J.; Castilho, Paula C.In this work, we report the in vitro inhibitory potential of Rumex maderensis methanolic extracts (leaves, flowers, and stems) towards key digestive enzymes linked to type-2 diabetes and obesity (α-amylase, α-glucosidase, pancreatic lipase). The inhibitory activity towards aldose reductase and glycation of bovine serum albumin (BSA) is also reported; in these latter assays, the effect of simulated digestion on ...
Fish processing industry residues: a review of valuable products extraction and...
Ideia, Pedro; Pinto, Joana; Ferreira, Rui; Figueiredo, Leandro; Spínola, Vítor; Castilho, Paula C.Fish processing industry has experienced significant growth, playing an important role in the world economy. The increased exploration of marine resources contributes to the generation of considerable amounts of biowaste, which ends up as discards. In the face of the resultant disposal and environmental problems, many efforts have been made to deal with the fishery waste in more efficient ways. Nowadays, these ...
Evaluation of Rubus grandifolius L. (wild blackberries) activities targeting ma...
Spínola, Vítor; Pinto, Joana; Llorent-Martínez, Eulogio J.; Tomás, Helena; Castilho, Paula C.Rubus grandifolius Lowe (wild blackberries) is an endemic species from Madeira Archipelago (Portugal) used in folk medicine for alleviating diabetic complications. In this work, R. grandifolius methanolic extracts were analysed for in vitro inhibitory effect on digestive enzymes linked to type-2 diabetes, as well as aldose reductase activity and protein glycation. The phenolic composition, antioxidant and cytot...
Polyphenols of Myrica faya inhibit key enzymes linked to type II diabetes and o...
Spínola, Vítor; Llorent-Martínez, Eulogio J.; Castilho, Paula C.Myrica faya Aiton (fire tree, faya) is an underused species with a diverse flavonoid composition (anthocyanins, flavonols, ellagitannins) which can promote positive effects on human health. M. faya has been reported to possess high antioxidant activities, but its potential in the prevention of type II diabetes has not been evaluated so far. In the present study, eight M. faya samples from different areas of Mad...
Changes in the phenolic compositions of Elaeagnus umbellata and Sambucus lanceo...
Spínola, Vítor; Pinto, Joana; Llorent-Martínez, Eulogio J.; Castilho, Paula C.In this work, the phenolic composition of E. umbellata leaves and berries is reported. Berries were rich in flavonols, whereas leaves presented abundant flavonols and ellagitannins. Then, the enzyme-inhibitory properties, anti-glycation and antioxidant activities of E. umbellata and Sambucus lanceolata (its phenolic profile has been already established in a previous work) were tested by several in vitro assays ...
Release of health-related compounds during in vitro gastro-intestinal digestion...
Quintana, Gabriel; Spínola, Vítor; Martins, Gonçalo N.; Gerbino, Esteban; Gómez-Zavaglia, Andrea; Castilho, Paula C.Okara is a highly perishable by-product remaining after filtration of the smashed soybeans seeds in the production of soymilk. Due to its nutritional value, different approaches have been developed to use it as functional ingredient. Fermentation of okara appears as an interesting strategy to preclude spoilage, providing a more stable matrix to be incorporated in the formulation of functional foods. Okara has a...
Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and...
Spínola, Vítor; Castilho, Paula C.The qualitative and quantitative characterization of Madeira moneywort (Sibthorpia peregrina L.) compounds was investigated for the first time. The antioxidant activity and the effect of the methanolic extract on digestive enzymes activity linked to type-2 diabetes and obesity were also determined by in vitro assays. A total of 56 components were characterized in S. peregrina. Phenylethanoids glycosides (PhEGs)...
Antioxidant polyphenols of Madeira sorrel (Rumex maderensis): How do they survi...
Spínola, Vítor; Llorent-Martínez, Eulogio J.; Castilho, Paula C.In this work, we report the phytochemical profile and antioxidant activity of different morphological parts of Rumex maderensis Lowe (Polygonaceae), a wild leafy-vegetable growing in Madeira Island (Portugal). Methanol extracts from leaves, flowers, and stems were submitted to high-performance liquid chromatography with mass spectrometry detection to obtain the phytochemical profile, which allowed the identific...