6 documents found, page 1 of 1
The ADnet Bayesian belief network for alder decline: Integrating empirical data...
Gomes Marques, Inês; Vieites-Blanco, Cristina; Rodríguez-González, Patricia M.; Segurado, Pedro; Marques, Marlene; Barrento, Maria J.The globalization in plant material trading has caused the emergence of invasive pests in many ecosystems, such as the alder pathogen Phytophthora ×alni in European riparian forests. Due to the ecological importance of alder to the functioning of rivers and the increasing incidence of P. ×alni-induced alder decline, effective and accessible decision tools are required to help managers and stakeholders control t...
Ação da leptina no metabolismo da glucose das células de Sertoli: impacto na fe...
Martins, Ana D.; Moreira, Ana C.; Sá, Rosália; Monteiro, Mariana P.; Sousa, Mário; Carvalho, Rui A.; Silva, Branca M.; Oliveira, Pedro F.Nos últimos anos os hábitos alimentares e o estilo de vida têm vindo a tornar-se pouco saudáveis, favorecendo o desenvolvimento de doenças metabólicas (por exemplo Diabetes tipo 2 e obesidade). A leptina é uma hormona produzida no tecido adiposo responsável pela sensação de saciedade. Os níveis desta hormona estão positivamente relacionados com a quantidade de gordura corporal e têm sido descritos efeitos negat...
Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxi...
Moreira, Ana C.; Branco, Ana F.; Sampaio, Susana F.; Cunha-Oliveira, Teresa; Martins, Tatiana R.; Holy, Jon; Oliveira, Paulo J.; Sardão, Vilma A.The cardiotoxicity induced by the anti-cancer doxorubicin involves increased oxidative stress, disruption of calcium homeostasis and activation of cardiomyocyte death. Nevertheless, antioxidants and caspase inhibitors often show little efficacy in preventing cell death. We hypothesize that a caspase-independent cell death mechanism with the release of the apoptosis-inducing factor from mitochondria is involved ...
β-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one ...
Branco, Ana F.; Moreira, Ana C.; Cunha-Oliveira, Teresa; Couto, Renata; Sardão, Vilma A.; Rizvanov, Albert A.; Palotas, Andras; Oliveira, Paulo J.Neuro-hormonal regulation of cardiac function via cathecol-amines results in increased heart rate and contractility. A persistent adrenergic tone, however, is an insult to the heart, affecting its regular homeostasis, altering morphology and gene expression patterns, as well as inducing apoptosis of cardio-myocytes. At the same time as being the main oxygen consumers, mitochondria are also key to the energy pro...
Resveratrol affects differently rat liver and brain mitochondrial bioenergetics...
Moreira, Ana C.; Silva, Ana M.; Santos, M. S.; Sardão, Vilma A.Resveratrol (3,5,40-trihydroxy-trans stilbene) is commonly recognized by its antioxidant properties. Despite its beneficial qualities, the toxic effects of this natural compound are still unknown. Since mitochondria are essential to support the energy-dependent regulation of several cell functions, the objective of this study was to evaluate resveratrol effects on rat brain and liver mitochondrial fractions fro...
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug...
Pereira, Cláudia V.; Moreira, Ana C.; Pereira, Susana P.; Machado, Nuno G.; Carvalho, Filipa S.; Sardão, Vilma A.; Oliveira, Paulo J.Mitochondria are recognized as the producers of the majority of energy cells need for their normal activity. After the initial comprehension of how mitochondrial oxidative phosphorylation produces energy, mitochondrial research was not a priority for most cell biologists until novel mitochondrial functions were identified. In fact, it is now known that mitochondria are not only involved in cell calcium homeosta...