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Isolation and Identification of Cytotoxic Compounds Present in Biomaterial Life®

Ferreira, Maria Beatriz; Pereira, Nelson A. M.; Marto, Carlos Miguel; Cardoso, Miguel; Amaro, Inês; Coelho, Ana; Saraiva, José; Spagnuolo, Gianrico

Direct pulp capping consists of a procedure in which a material is directly placed over the exposed pulp to maintain dental vitality. Although still widely used in clinical practice, previous in vitro studies found that the biomaterial Life® presented high cytotoxicity, leading to cell death. This study aimed to identify the Life® constituents responsible for its cytotoxic effects on odontoblast-like cells (MDP...


A Review of Prolonged Post-COVID-19 Symptoms and Their Implications on Dental M...

Chakraborty, Trishnika; Jamal, Rizwana Fathima; Battineni, Gopi; Teja, Kavalipurapu Venkata; Marto, Carlos Miguel; Spagnuolo, Gianrico

The available data regarding the short and long-term consequences of COVID-19 is still insufficient. This narrative review aims to provide information on the prolonged COVID-19 symptoms in recovered patients and their implications during dental management. Additionally, this manuscript highlights the oral manifestations of COVID-19 and its management. A systematic search was conducted in PubMed, Embase, Cochran...


Effect of Cavity Disinfectants on Dentin Bond Strength and Clinical Success of ...

Coelho, Ana; Amaro, Inês; Rascão, Beatriz; Marcelino, Inês; Paula, Anabela; Saraiva, José; Spagnuolo, Gianrico; Ferreira, Manuel Marques

Cavity disinfection becomes an important step before a dental restorative procedure. The disinfection can be obtained cleaning the dental cavity with antimicrobial agents before the use of adhesive systems. The aim of this study was to conduct a systematic review on the effect of different cavity disinfectants on restorations' adhesion and clinical success. A search was carried out through the Cochrane Library,...


Efficacy and Patient's Acceptance of Alternative Methods for Caries Removal-a S...

Cardoso, Miguel; Coelho, Ana; Lima, Rui; Amaro, Inês; Paula, Anabela; Marto, Carlos Miguel; Sousa, José; Spagnuolo, Gianrico; Ferreira, Manuel Marques

Dental caries is a disease of dental hard tissues, considered the most common non-communicable disease worldwide. Conventional treatments for caries removal are often associated with pain and fear, so different therapeutic approaches have been developed towards more conservative and pleasant treatments. This systematic review aimed to assess the efficacy and patient's acceptance of alternative methods for carie...


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