3 documents found, page 1 of 1
Characterization and evaluation of the enzymatic activity of tetanus toxin subm...
Sartori,Giselle Pacifico; Costa,Andréa da; Macarini,Fernanda Lúcio dos Santos; Mariano,Douglas Oscar Ceolin; Pimenta,Daniel CarvalhoAbstract Background Tetanus toxin blocks the release of the inhibitory neurotransmitters in the central nervous system and causes tetanus and its main form of prevention is through vaccination. The vaccine is produced by inactivation of tetanus toxin with formaldehyde, which may cause side effects. An alternative way is the use of ionizing radiation for inactivation of the toxin and also to improve the potentia...
Protein identification from the parotoid macrogland secretion of Duttaphrynus m...
Mariano,Douglas Oscar Ceolin; Messias,Marcela Di Giacomo; Spencer,Patrick Jack; Pimenta,Daniel CarvalhoABSTRACT Background: Bufonid parotoid macrogland secretion contains several low molecular mass molecules, such as alkaloids and steroids. Nevertheless, its protein content is poorly understood. Herein, we applied a sample preparation methodology that allows the analysis of viscous matrices in order to examine its proteins. Methods: Duttaphrynus melanostictus parotoid macrogland secretion was submitted to ion-ex...
New insights into the structural characteristics of irradiated crotamine
Oliveira,Karina Corleto; Spencer,Patrick Jack; Ferreira Jr,Rui Seabra; Nascimento,Nanci